Publications by authors named "Stefanie van der Wees"
Immune checkpoint inhibitors (ICI) have revolutionized the treatment landscape of advanced malignancies, but come with a diverse spectrum of immune-related adverse events (irAEs). Mechanistic studies can aid the transition from expert-opinion to evidence-based irAE treatment strategies. We aimed to longitudinally characterize peripheral blood T and B cell dynamics in ICI-treated patients by multicolor flow cytometry and serum multiplex immunoassay at baseline, ± 3 weeks and ± 6 weeks or upon clinically relevant irAEs.
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- Current whole sporozoite (SPZ) vaccines show limited effectiveness in malaria-endemic regions, possibly due to reduced immune responses from prior malaria exposure.
- Researchers have developed a method to enhance SPZ vaccine immunogenicity by attaching a TLR7 agonist-based adjuvant, leading to significantly higher immune responses, including a 35-fold increase in pro-inflammatory IL-6 production.
- Mice immunized with this enhanced SPZ vaccine demonstrated improved production of specific immune cells, suggesting that this chemical augmentation strategy could make malaria vaccines more effective.