Publications by authors named "Stefanie Pfeiffer"
Article Synopsis
- Researchers tested 18 dihydrochalcone compounds against periodontal disease using human gingival fibroblast cells to evaluate their effects on inflammation.
- The most effective compound identified was 2',4,4',6'-tetrahydroxy 3-methoxydihydrochalcone, which significantly reduced IL-8 release by up to 94%.
- Results suggest that specific structural features, such as hydroxyl substitutions and electronegative atoms, enhance anti-inflammatory activity, providing insights for developing new oral care products.
The triggers for the onset of oral diseases are still poorly understood. The aim of this study was to characterize the oral bacterial community in healthy humans and its association with nutrition, oral hygiene habits, and the release of the inflammatory marker IL-8 from gingival epithelial cells (GECs) with and without stimulation by bacterial endotoxins to identify possible indicator operational taxonomic units (OTUs) associated with inflammatory marker status. GECs from 21 healthy participants (13 females, 8 males) were incubated with or without addition of bacterial lipopolysaccharides (LPSs), and the oral microbiota was profiled using 16S rRNA gene-targeted sequencing.
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