Publications by authors named "Stefanie Krantz"
Low serum levels of 1α, 25-dihydroxyvitamin D3 (VD3) are associated with a higher mortality in trauma patients with sepsis or ARDS. However, the molecular mechanisms behind this observation are not yet understood. VD is known to stimulate lung maturity, alveolar type II cell differentiation, or pulmonary surfactant synthesis and guides epithelial defense during infection.
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- The genome of coronaviruses like SARS-CoV-2 includes two critical proteases: a papain-like protease and a main protease (M), which is essential for processing the viral polyprotein and some host proteins.
- The main protease (M) is activated through autoproteolysis and is involved in cleaving viral and host proteins, impacting the innate immune response.
- An analysis using LC-MS identified 445 cleavage events from over 300 proteins for SARS-CoV-2, along with additional events for SARS-CoV and hCoV-NL63, providing insights into the specificity of these proteases and potential new substrates for study.