Publications by authors named "Stefania d'Aria"
Article Synopsis
- MCT1 is crucial for aiding T cells in exporting lactic acid, which is necessary for their function during viral infections.
- MCT1-deficient T cells showed impaired expansion and memory development in response to viral infections, leading to functional exhaustion instead.
- The deficiency in MCT1 disrupted metabolic processes like glycolysis and nucleotide synthesis, preventing effective T cell responses against viruses.
Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes.
View Article and Find Full Text PDFT-cell metabolism is central to the shaping of a successful immune response. However, there are pathological situations where T cells are rendered dysfunctional and incapable of eliminating infected or transformed cells. Here, we review the current knowledge on T-cell metabolism and how persistent antigenic stimulation, in the form of cancer and chronic viral infection, modifies both metabolic and functional pathways in T cells.
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