Publications by authors named "Stefania Volante"
Invasiveness modulation of glioma cells by copper complex-loaded nanoarchitectures.
Agata Zamborlin Francesca Pagliari Maria Laura Ermini Valentina Frusca Daniel García-Calderón Stefania Volante
Colloids Surf B Biointerfaces
January 2025
Article Synopsis
- Gliomas, a severe type of brain tumor, frequently recur and can metastasize, with limited existing treatments for reducing metastasis, highlighting a need for new anti-metastatic agents.
- Copper complexes have shown potential as effective anti-metastatic agents, but their use may disrupt healthy tissue balance; thus, incorporating these complexes into nano-architectures can enhance targeted delivery and minimize side effects.
- Newly developed copper complex-loaded nano-architectures (CuLNAs) significantly reduce glioma cell migration without negatively affecting cell growth, and they modulate key genes involved in the epithelial-to-mesenchymal transition, presenting a promising strategy for anticancer therapies.
In the synthesis of metal-organic frameworks (MOFs), the choice of the metal precursor plays a key role because of the influence that it can exert on the crystallization kinetics. The present work explores the use of metal-carbamato complexes for the synthesis of benchmark MOFs, namely HKUST-1 and UiO-66. Cu(OCNEt)·2NHEt and Zr(OCNEt), prepared using straightforward CO fixation reactions starting from the corresponding metal chlorides and diethylamine, were employed as metal precursors for MOF formation.
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