Aluminum Concentration Is Associated with Tumor Mutational Burden and the Expression of Immune Response Biomarkers in Colorectal Cancers.

Environmental pollution poses a significant risk to public health, as demonstrated by the bioaccumulation of aluminum (Al) in colorectal cancer (CRC). This study aimed to investigate the potential mutagenic effect of Al bioaccumulation in CRC samples, linking it to the alteration of key mediators of cancer progression, including immune response biomarkers. Aluminum levels in 20 CRC biopsy samples were analyzed using inductively coupled plasma mass spectrometry (ICP-MS).

Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors.

Background And Aims: The aim of this study was to investigate possible associations among markers of mineralization, plaque instability and the main risk factors of atherosclerosis.

Methods And Results: A Tissue MicroArray containing 52 samples of calcified carotid plaques from 52 symptomatic and asymptomatic patients were built. TMA serial sections were used to study the expression of inflammatory and mineralization markers (BMP-2, BMP-4, VDR, RANKL, Osteopontin, Sclerostin, β-catenin and calmodulin) by immunohistochemistry.

Solitary fibrous tumour of thyroid: report of two cases with immunohistochemical features and literature review.

Solitary fibrous tumour (SFT) is a rare tumour principally found in adults in the pleural cavity. Extrapleural occurrences are rare. Two cases of SFT of the thyroid gland are described in this paper showing their distinctive microscopical architecture, namely "patternless growth pattern".

Long-term follow-up of cellular proliferation as a predictive index for the relapse of nasal polyposis.

Background: The objective of this study was to identify a reproducible clinical parameter for predicting relapses of nasal polyposis after surgery.

Methods: Ninety-three patients who had undergone ethmoidectomy of bilateral nasal polyps were followed for 3 years. Nasal polyps were obtained from all patients, and cellular suspensions were analyzed individually using flow cytometry.