Publications by authors named "Stefania Modafferi"
Article Synopsis
- * New research shows that DNA breaks can actually trigger the production of non-coding RNAs (ncRNAs) that might be essential for signaling and repairing DNA damage.
- * The study reviews how certain histone modifications are influenced by these ncRNAs, suggesting potential new approaches for targeting DNA repair in therapies.
Prenatal paracetamol exposure has been associated with neurodevelopmental outcomes in childhood. Pharmacoepigenetic studies show differences in cord blood DNA methylation between unexposed and paracetamol-exposed neonates, however, causality and impact of long-term prenatal paracetamol exposure on brain development remain unclear. Using a multi-omics approach, we investigated the effects of paracetamol on an model of early human neurodevelopment.
View Article and Find Full Text PDFNeuronal differentiation of pluripotent stem cells is an established method to study physiology, disease, and medication safety. However, the sequence of events in human neuronal differentiation and the ability of models to recapitulate early brain development are poorly understood. We developed a protocol optimized for the study of early human brain development and neuropharmacological applications.
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