Publications by authors named "Stefania Melini"
Chronic lipid overnutrition has been demonstrated to promote cardiac dysfunction resulting from metabolic derangement, inflammation, and fibrosis. Oleoylethanolamide (OEA), an endogenous peroxisome proliferator activating receptor (PPAR)-α agonist, has been extensively studied for its metabolic properties. The aim of this study was to determine if OEA has beneficial effects on high-fat diet (HFD)-induced cardiac disruption in obese mice, focusing on the underlying pathological mechanisms.
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- - The study investigates how early-life infections affect liver damage and inflammation in young epileptic rats, focusing on gender differences in response to these infections.
- - Infected male rats showed a stronger inflammatory response and higher levels of pro-inflammatory markers, while female rats displayed significant changes in lipid metabolism and reduced mitochondrial function.
- - The findings highlight that early infections can worsen liver conditions in epileptic individuals differently based on sex, emphasizing the need for tailored treatment approaches.
Chronic kidney disease (CKD) development after acute kidney injury (AKI) involves multiple mechanisms, including inflammation, epithelial-mesenchymal transition (EMT), and extracellular matrix deposition, leading to progressive tubulointerstitial fibrosis. Recently, a central role for peroxisome-proliferator activated receptor (PPAR)-α has been addressed in preserving kidney function during AKI. Among endogenous lipid mediators, oleoylethanolamide (OEA), a PPAR-α agonist, has been studied for its metabolic and anti-inflammatory effects.
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- * The researchers developed a high-content fluorescence microscopy method to identify senolytics, utilizing differences in autofluorescence levels between senescent and non-senescent cells for detection.
- * Their validation showed that the first-generation senolytics effectively reduced senescent cell counts without affecting non-senescent cells, demonstrating the method's potential for screening new senolytic compounds.