Cognitive Status According to Homocysteine and B-Group Vitamins in Elderly Adults.

Objectives: To determine the association between hyperhomocysteinemia and cognitive function, taking into account the effect of B group vitamin (BGV) deficiency.

Design: Cross-sectional.

Setting: Memory Clinic, S.

Serum levels of hydroperoxides and multimorbidity among older patients with mild cognitive impairment or late-onset Alzheimer's disease.

Background: Oxidative stress (OxS) might be involved in the pathogenesis of late-onset Alzheimer disease (LOAD); noteworthy, the presence of multimorbidity is regarded as a common denominator of OxS and dementia.

Aim: To evaluate the contribution of multimorbidity to OxS in LOAD and mild cognitive impairment (MCI).

Methods: Serum hydroperoxides and multimorbidity (CIRS-CI scale) were evaluated in 46 Controls, 104 MCI and 75 LOAD.

Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment.

Mild cognitive impairment (MCI) is regarded as a prodromal phase of late onset Alzheimer's disease (LOAD). It has been proposed that oxidative stress (OxS) might be implicated in the pathogenesis of LOAD. The aim of this study was to investigate whether a redox imbalance measured as serum level of hydroperoxides (i.

Oxidative balance, homocysteine, and uric acid levels in older patients with Late Onset Alzheimer's Disease or Vascular Dementia.

This study aimed to investigate whether Late Onset Alzheimer's Disease (LOAD) and Vascular Dementia (VAD) might be associated with a distinct profile of oxidative stress (OxS) peripheral markers. Serum levels of hydroperoxides, homocysteine, advanced oxidation protein products, uric acid, thiols, and total and residual antioxidant power were assessed in 103 mild cognitive impairment (MCI), 89 LOAD, 54 VAD patients and 48 Controls. Compared with Controls, a similar oxidative unbalance (high hydroperoxides and low residual antioxidant power) was observed in MCI, LOAD and, although less pronounced, VAD.

Subsyndromal delirium and its determinants in elderly patients hospitalized for acute medical illness.

Background: In older individuals, acute medical illnesses and admission to hospital are often associated with a deterioration of cognitive status, also in the absence of dementia and full-blown delirium. We evaluated the prevalence of subsyndromal delirium (SSD) and its correlates in a sample of elderly medical inpatients.

Methods: From 763 consecutive inpatients, 325 participants with known dementia or delirium were excluded, whereas 438 (mean age: 80.

Systemic oxidative stress in older patients with mild cognitive impairment or late onset Alzheimer's disease.

A large body of evidences obtained in human and animal brain tissue suggest a role of oxidative stress (OxS) in the pathogenesis of late onset Alzheimer's disease (LOAD); on the contrary, data on peripheral markers of OxS in LOAD are still controversial. We evaluated the serum levels of products of lipid peroxidation, hydroperoxides, advanced oxidation protein products, total and residual antioxidant power, thiols, and uric acid in a sample of 334 older individuals: 101 LOAD patients, 134 patients with mild cognitive impairment (MCI), and 99 controls. At univariate analysis, serum hydroperoxides were higher while residual antioxidant power was lower in MCI and LOAD compared with in controls.

Prior antiplatelet drug use and short-term mortality in older patients with acute ischemic stroke (AIS).

Some studies suggest that previous treatment with antiplatelet agents (AA) might reduce ischemic stroke severity and improve outcomes in terms of clinical deficits or mortality. We evaluated the effect of the prior chronic use of AA on short-term (30 days) mortality in a sample of consecutive patients with AIS. Four hundred thirty-nine older patients (>65 years) with "major" AIS (modified Rankin scale ≥ 3) consecutively admitted to the University ward of Internal Medicine or Geriatrics were enrolled.