Publications by authors named "Stefania Latini"
Article Synopsis
- PACAP and its receptor PAC1-R are expressed in mouse cumulus cells post-LH surge, influencing ovulation.
- PACAP enhances cumulus expansion, prevents cell death, and boosts oocyte maturation in the presence of hypoxanthine.
- The findings suggest that PACAP's role in ovulation and fertilization is tied to gonadotropin and growth factor interactions.
Pituitary adenylate cyclase activating polypeptide (PACAP) is transiently expressed in preovulatory follicles of different species and positively affects parameters correlated with the ovulatory process. It has also been shown to be expressed in the interstitial tissue and in interstitial glandular cells in the proximity of primordial and preantral follicles. The aim of the present study was to investigate whether PACAP influences the recruitment of primordial follicles and the growth and differentiation of preantral follicles.
View Article and Find Full Text PDFPituitary adenylate cyclase-activating polypeptide (PACAP) is a bioactive peptide transiently expressed in preovulatory follicles. PACAP acts by interacting with three types of PACAP receptors. PACAP type I receptor (PAC(1)-R), which binds specifically to both PACAPs and vasoactive intestinal polypeptide (VIP), although with lower affinity, and two VIP receptors, VPAC(1)-R and VPAC(2)-R, which bind to PACAP and VIP with equal affinity.
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