Publications by authors named "Stefan-Benno Kaehler"
Clin Neurophysiol
June 2019
Article Synopsis
- - The study investigates Botulinum neurotoxin serotype D (BoNT/D) as a potential alternative treatment for patients who do not respond to the widely used BoNT/A and B due to the formation of neutralizing antibodies.
- - BoNT/D was produced in E. coli and tested for its efficacy in both mouse tissues and human volunteers, showing that while it's less potent, it can produce similar effects with a higher dosage and shorter action duration.
- - The findings suggest BoNT/D could be a viable option for patients who don't respond to other serotypes, despite its lower effectiveness compared to approved treatments.
