Publications by authors named "Stefan-Adrian Niculescu"
Postural disorders in children and adolescents have an increasing incidence. The aim of this study was to identify the type of postural defects in school-age and preschool children, as well as the external risk factors determined by an inadequate lifestyle. The research included 134 children aged between 5 and 18 years, in whom postural defects were identified.
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- Osteosarcoma is the most common primary bone tumor in children and adolescents, typically found in the long bones, particularly at the metaphysis.
- Diagnosis relies on pathology exams since there are no specific diagnostic tools, and treatment involves a multidisciplinary team.
- Limb salvage surgery is the preferred surgical treatment when feasible, but there is no consensus on the best reconstructive procedures; practitioners must weigh the impacts of limb length inequality versus amputation on the patient's quality of life and psychosocial wellbeing.
infection (CDI) is the most common cause of healthcare-associated diarrhea and among adults, the worldwide incidence rate of the infection is increasing. There is a small amount of data in the literature for pediatric patients, but most indicate an increasing trend. is a constituent of the normal microbiota; however, under specific conditions that cause a disruption of the normal bacterial flora, colonization of and the released toxins that cause inflammation and mucosal damage occurs.
View Article and Find Full Text PDFThe main malignant tumor of the bone tissue is represented by osteosarcoma, neoplasia with a reserved prognosis and an unpredictable evolution, often aggressive. Cell cycle disruption is one of the complex biomolecular mechanisms involved in the progression of osteosarcomas. In this study, we analyzed the immunoexpression of Ki67, p53 and cyclin D1 for 18 primitive osteosarcomas in relation to the clinicopathological prognosis parameters of the lesions.
View Article and Find Full Text PDFThe main objective of this study is to highlight the efficiency of different therapeutic means in patients with ankylosing spondylitis, resulting in the improvement of their quality of life. We conducted a randomized, longitudinal, controlled trial on 92 patients with ankylosing spondylitis over a period of 6 years. Disease activity was assessed using the BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) score.
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