Development and external validation of a clinical prediction model for predicting quality of recovery up to 1 week after surgery.

The Quality of Recovery Score-40 (QoR-40) has been increasingly used for assessing recovery after patients undergoing surgery. However, a prediction model estimating quality of recovery is lacking. The aim of the present study was to develop and externally validate a clinical prediction model that predicts quality of recovery up to one week after surgery.

Updating Clinical Prediction Models: An Illustrative Case Study.

The performance of clinical prediction models tends to deteriorate over time. Researchers often develop a new prediction if an existing model performs poorly at external validation. Model updating is an efficient technique and promising alternative to the de novo development of clinical prediction models.

The effect of midazolam as premedication on the quality of postoperative recovery after laparotomy: a randomized clinical trial.

Purpose: Despite the uncertain effects of anxiolytic premedication with benzodiazepines on the quality of postoperative recovery, perioperative benzodiazepine administration is still a common practice in many hospitals. We evaluated the effect of premedication with midazolam on the quality of recovery in hospitalized patients undergoing a laparotomy.

Methods: We conducted a single-centre randomized placebo-controlled, double-blinded clinical trial from July 2014 to September 2015.

Implication of UGT2B15 Genotype Polymorphism on Postoperative Anxiety Levels in Patients Receiving Lorazepam Premedication.

Background: Lorazepam is used as premedication for its anxiolytic properties. The UGT2B15 genotype is of importance for the metabolism of lorazepam. The clinical effect of genetic polymorphisms in UGT2B15 genotype on the treatment of anxiety levels in same-day surgery patients receiving lorazepam, however, is unknown.

Effectiveness of benzodiazepine premedication on recovery in day-case surgery: a systematic review with meta-analysis.

Introduction: Benzodiazepines are frequently used as a premedication. In day-case surgery, anesthetists are reluctant to administer benzodiazepines preoperatively for reasons of delayed recovery. However, premedication with benzodiazepines might be beneficial regarding postoperative somatic symptoms/complaints (i.

Potential neurotoxicity of anesthetic drugs in young children: who cares? A survey among European anesthetists.

Background: Potential neurotoxicity of anesthetic drugs is currently one of the most intensely discussed issues in pediatric anesthesia. Prospective human data are sorely lacking and there is an on-going debate among experts in the field whether one should (or can) extrapolate animal data to humans. Data regarding the thoughts of practicing anesthetists regarding this topic have not been published.

Lorazepam does not improve the quality of recovery in day-case surgery patients: a randomised placebo-controlled clinical trial.

Background: In day-case surgery, the effects of the anxiolytic lorazepam as premedication on the quality of postoperative recovery are unknown.

Objective: To evaluate whether lorazepam as a premedication beneficially affects quality of recovery (primary outcome) and psychological manifestations (secondary outcome) after day-case surgery.

Design: A randomised, double-blind, placebo-controlled clinical trial.