Publications by authors named "Stefan Templin"
Background: Studies comparing long-term outcomes between non-vitamin K antagonist (VKA) oral anticoagulant agents (direct oral anticoagulant agents [DOACs]) and VKA anticoagulant agents after transcatheter aortic valve replacement (TAVR) are scarce, with conflicting results.
Objectives: The aim of this study was to examine the periprocedural, short-term, and long-term safety and effectiveness of DOACs vs VKAs in patients undergoing TAVR via femoral access with concomitant indications for oral anticoagulation.
Methods: Consecutive patients undergoing transfemoral TAVR in the prospective national SwissTAVI Registry between February 2011 and June 2021 were analyzed.
Article Synopsis
- Stroke following transcatheter aortic valve replacement (TAVR) presents significant health risks, with ongoing research needed to fully understand its predictors and long-term effects.
- In a study involving nearly 12,000 TAVR patients tracked from 2011 to 2021, the 30-day stroke rate was found to be 3.0%, with most events occurring within the first 48 hours.
- The risk of stroke was notably higher in TAVR patients compared to the general population during the first two years post-procedure, after which their risk leveled off to match that of their peers.
Objective: It has not been solved whether subjects carrying the minor alleles of the -455T>C or -482C>T single nucleotide polymorphisms (SNPs) in the apolipoprotein-C3-gene (APOC3) have an increased risk for developing fatty liver and insulin resistance. We investigated the relationships of the SNPs with hepatic APOC3 expression and hypothesized that visceral obesity may modulate the effects of these SNPs on liver fat and insulin sensitivity (IS).
Methods: APOC3 mRNA expression and triglyceride content were determined in liver biopsies from 50 subjects.