Cognitive Function During Opioid Tapering in Patients with Chronic Pain: A Prospective Cohort Study.

Purpose: Evidence for efficacy and safety lacks for long-term opioid therapy in patients with chronic non-cancer pain and adverse effects, including affection of cognitive function and quality of life, is of concern. We aimed to investigate cognitive function and health-related quality of life in patients with chronic non-cancer pain during opioid reduction.

Patients And Methods: At two multidisciplinary pain centers, all patients with planned opioid reduction were screened for eligibility.