Publications by authors named "Stefan Stoica"
Article Synopsis
- Glioblastoma is a highly fatal brain tumor with chromosomal alterations affecting oncogenes and tumor suppressors, and research identified 6q27 as a poor prognostic marker.
- Using a combination of CRISPR, transcriptomic data, and mouse models, the study explored Pde10a as a potential tumor suppressor in the 6q27 region and found its suppression leads to aggressive tumor behavior and treatment resistance.
- Pde10a suppression was linked to enhanced PI3K/AKT signaling and a change in tumor cell characteristics, suggesting glioblastoma patients with Pde10a loss may have worse outcomes but might benefit from PI3K inhibitors.
Purpose: Missense mutated von Hippel Lindau (VHL) protein (pVHL) maintains intrinsic function but undergoes proteasomal degradation and tumor initiation and/or progression in VHL disease. Vorinostat can rescue missense mutated pVHL and arrest tumor growth in preclinical models. We asked whether short-term oral vorinostat could rescue pVHL in central nervous system hemangioblastomas in patients with germline missense VHL.
View Article and Find Full Text PDFTo understand the neural basis of behavior, it is important to reveal how movements are planned, executed, and refined by networks of neurons distributed throughout the nervous system. Here, we report the neuroanatomical organization and behavioral roles of cerebellospinal (CeS) neurons. Using intersectional genetic techniques, we find that CeS neurons constitute a small minority of excitatory neurons in the fastigial and interpositus deep cerebellar nuclei, target pre-motor circuits in the ventral spinal cord and the brain, and control distinct aspects of movement.
View Article and Find Full Text PDF