Publications by authors named "Stefan Schering"
Purpose: The approach to limit therapy in very old intensive care unit patients (VIPs) significantly differs between regions. The focus of this multicenter analysis is to illuminate, whether the Clinical Frailty Scale (CFS) is a suitable tool for risk stratification in VIPs admitted to intensive care units (ICUs) in Germany. Furthermore, this investigation elucidates the impact of therapeutic limitation on the length of stay and mortality in this setting.
View Article and Find Full Text PDFNitric oxide synthase is up-regulated in muscle fibers in muscular dystrophy.
Biochem Biophys Res Commun
September 2006
Article Synopsis
- Nitric oxide (NO) plays a crucial role in regulating functions in skeletal muscle, with a specific focus on its relationship to Duchenne muscular dystrophy (DMD).
- Contrary to earlier beliefs that only the neuronal isoform (NOS1) was lost in DMD, recent studies show that all three NOS isoforms (NOS1, NOS2, NOS3) are present in the muscle tissue of both healthy and DMD-affected individuals.
- This research indicates that the muscle degeneration in DMD may stem from a deficiency of NO due to superoxides interfering with its action, rather than a decrease in NOS production itself.
Skeletal muscle functions regulated by NO are now firmly established. However, the knowledge about the NO synthase (NOS) expression related to a defined fibre type in human skeletal muscles necessitates further clarification. To address this issue, we examined localization of NOS isoforms I, II and III, in human skeletal muscles employing immunocytochemical labeling with tyramide signal amplification complemented with enzyme histochemistry and Western blotting.
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