Derivation and External Validation of the Ottawa Bloodstream Infection Model for Acutely Ill Adults.

Background: Knowing the probability that patients have a bloodstream infection (BSI) could influence the ordering of blood cultures and interpretation of their preliminary results. Many previous BSI probability models have limited applicability and accuracy. This study used currently recommended modeling techniques and a large sample to derive and validate the Ottawa BSI Model.

The Independent Association of Plasma and Red Blood Cell Zinc Concentrations with Long-Term Outcomes of Hospitalized Patients.

Background: Plasma and RBC zinc values are unrelated in hospitalized patients. The independent association of these values with important patient outcomes is unknown.

Objectives: Measure the independent association of plasma and RBC zinc with outcomes in hospitalized patients.

Relationship between Plasma Zinc and Red Blood Cell Zinc Levels in Hospitalized Patients.

Background: Patient zinc stores are quantified with plasma or red blood cell (RBC) measures. The relationship between these 2 measures of zinc status has not been determined in a broad population of hospitalized patients.

Methods: Both plasma zinc and RBC zinc were prospectively collected and measured in 252 consenting patients admitted urgently to hospital.

Concurrent external validation of bloodstream infection probability models.

Objective: Accurately estimating the likelihood of bloodstream infection (BSI) can help clinicians make diagnostic and therapeutic decisions. Many multivariate models predicting BSI probability have been published. This study measured the performance of BSI probability models within the same patient sample.

The Prognostic Value of Serum Zinc Levels in Acutely Hospitalized Patients: a Systematic Review.

Several small studies have identified possible associations between low serum zinc levels and worse outcomes in patients acutely hospitalized for a variety of diseases. This study systematically evaluated all published literature to determine whether serum zinc might independently predict important outcomes in hospitalized patients. PubMed, Embase, and Cochrane Libraries databases were searched from 1970 to 2019 to identify all citations having the keyword "zinc" with hospital outcomes.

Factors associated with zinc levels in hospitalized patients: An observational study using routinely collected data.

Background: Zinc deficiency is easily treated and has been associated with worse outcomes in hospitalized patients. Zinc testing is time-consuming and relatively costly. We identified every zinc level measured at our teaching hospital and quantified how much zinc variation is explained by other hospital factors.

Reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype.

Cancer cells exhibit a wide range of metabolic phenotypes, ranging from strict aerobic glycolysis to increased mitochondrial respiration. The cause and utility of this metabolic variation is poorly understood. Given that cancer cells experience heavy selection within their microenvironment, survival requires metabolic adaptation to both extracellular and intracellular conditions.

Detection methods of circulating tumor cells in cutaneous melanoma: a systematic review.

The vast majority of melanoma-related deaths are due to disseminated malignancy. Many treated patients who are clinically disease-free will go on to relapse. Therefore, new prognostic tools must be developed to better assess metastatic potential and assist in patient management.