Closed-loop system to enhance slow-wave activity.

Objective: Recent evidence reports cognitive, metabolic, and sleep restoration benefits resulting from the enhancement of sleep slow-waves using auditory stimulation. Our objective is to make this concept practical for consumer use by developing and validating an electroencephalogram (EEG) closed-loop system to deliver auditory stimulation during sleep to enhance slow-waves.

Approach: The system automatically detects slow-wave sleep with 74% sensitivity and 97% specificity and optimally delivers stimulation in the form of 50 ms-long tones separated by a constant one-second inter-tone interval at a volume that is dynamically modulated such that louder tones are delivered when sleep is deeper.

Automatic characterization of sleep need dissipation dynamics using a single EEG signal.

In the two-process model of sleep regulation, slow-wave activity (SWA, i.e. the EEG power in the 0.