Publications by authors named "Stefan Miladinov Kovachev"
Article Synopsis
- * Results indicated that there was no statistically significant increased risk of endometrial pathology in women using vaginal oestrogen compared to those who did not, with no cases of atypical endometrial hyperplasia or endometrial intraepithelial neoplasia reported during the study.
- * The research supports the safety of topical vaginal oestrogens for treating genitourinary syndrome in menopausal women, highlighting their lesser impact on endometrial health compared to oral oestrogen
A Review on Inosine Pranobex Immunotherapy for Cervical HPV-Positive Patients.
Infect Drug Resist
June 2021
Article Synopsis
- * It emphasizes the importance of the host immune system in controlling HPV infections, noting that a well-functioning immune system can help eliminate the virus and prevent disease progression.
- * The analysis of various research studies from 1971-2021 indicates that IP shows significant clinical efficacy in treating HPV-related cervical changes and improving antiviral activity, potentially leading to the elimination of HPV from patients.
Article Synopsis
- This study investigates urologic complications following radical type C2 hysterectomy in cervical cancer patients, comparing outcomes with and without perioperative ureteral stenting.
- The study included 76 patients, randomly divided into two groups: one receiving ureteral stenting (24 patients) and the other not (52 patients), focusing on complications like ureter and bladder lesions as well as fistulas.
- Results showed that urologic complications were more common in the group without stenting (10.5% vs. 2.6%), indicating that stenting may help reduce these risks during and after surgery.*
Immunotherapy in patients with local HPV infection and high-grade squamous intraepithelial lesion following uterine cervical conization.
Immunopharmacol Immunotoxicol
August 2020
Article Synopsis
- The study examined the effect of inosine pranobex immunotherapy on clearing cervical HPV infections in women after surgical treatment for high-grade squamous intraepithelial lesions (HSIL).
- It involved 32 women, split into two groups: one receiving the immunotherapy and the other not, with follow-ups over 48 months to monitor HPV persistence and HSIL relapse.
- Results showed that the group receiving immunotherapy had a significantly higher clearance rate of high-risk HPV types and fewer HSIL relapses compared to the group that did not receive the treatment.
Article Synopsis
- The study investigates how changes in the vaginal microbiota may relate to the development of cervical cancer, focusing on women with FIGO I stage cervical cancer.
- Conducted between 2014 and 2019, the research included 32 women aged 38-55, revealing that a majority had disturbances in their vaginal microbiota, with bacterial vaginosis being the most common issue.
- The findings suggest that dysbiosis, characterized by an imbalance in vaginal bacteria, could potentially influence the development of cervical neoplasia, although the connection to HPV infection and cancer is not definitively established.
Local Probiotic Therapy for Vaginal Candida albicans Infections.
Probiotics Antimicrob Proteins
March 2015
Article Synopsis
- * 436 women with vaginal candidiasis were divided into two groups: one received standard azole treatment, while the other received the same treatment plus a vaginal probiotic starting five days after the azole.
- * Results showed that the group receiving probiotics had significantly better outcomes, with fewer clinical complaints and improved microbiological results, suggesting probiotics may enhance treatment effectiveness and help prevent recurrence.
Article Synopsis
- * Dysbacteriosis refers to disruptions in this microbial balance, often leading to vaginal infections and requiring correction for health restoration.
- * These disruptions can contribute to various obstetric and gynecological diseases, which pose significant risks to maternal and infant health, highlighting the need for prevention strategies.