Tb-DOTATOC Production Using a Fully Automated Disposable Cassette System: A First Step Toward the Introduction of Tb into the Clinic.

Tb is an interesting radionuclide for application in the treatment of neuroendocrine neoplasms' small metastases and single cancer cells because of its conversion and Auger-electron emission. Tb has coordination chemistry similar to that of Lu; therefore, like Lu, it can stably radiolabel DOTATOC, one of the leading peptides used for the treatment of neuroendocrine neoplasms. However, Tb is a recently developed radionuclide that has not yet been specified for clinical use.