Publications by authors named "Stefan H Keller"
Genes (Basel)
February 2024
Article Synopsis
- - A neutered male Weimaraner exhibited progressive neurological symptoms such as fecal incontinence, lethargy, and cognitive decline, beginning at nearly 5 years old and leading to euthanasia at 6 years, 7 months due to worsening conditions.
- - MRIs revealed brain atrophy and white matter pathology, while immunolabeling found autofluorescent granules in various tissues, suggesting a link to a lysosomal storage disease affecting myelin and causing significant neuroinflammation.
- - Whole genome sequencing identified a specific mutation related to myelin gene function, indicating a genetic basis for the dog's neurological deterioration, characterized by abnormal myelin structures in the brain and optic nerve.
