[(How) can progression of chronic kidney diseases be retarded?].

(How) can progression of chronic kidney diseases be retarded? Abstract. A variety of etiologically diverse chronic kidney diseases (CKD) may not only progress to end stage renal disease, but also increase cardiovascular morbidity and overall mortality. Once a critical mass of renal tissue has been irreversibly scarred, maladaptive mechanisms lead to progressive loss of the remaining kidney tissue, independent of the initial mechanism causing kidney injury.

Quantification of excretory renal function and urinary protein excretion by determination of body cell mass using bioimpedance analysis.

Background: Creatinine clearance (CrCl) based on 24 h urine collection is an established method to determine glomerular filtration rate (GFR). However, its measurement is cumbersome and the results are frequently inaccurate. The aim of this study was to develop an alternative method to predict CrCl and urinary protein excretion based on plasma creatinine and the quantification of muscle mass through bioimpedance analysis (BIA).