Publications by authors named "Stefan Eng"

We developed and evaluated the Digital Platform for Exercise (DPEx): a decentralized, patient-centric approach designed to enhance all aspects of clinical investigation of exercise therapy. DPEx integrated provision of a treadmill with telemedicine and remote biospecimen collection permitting all study procedures to be conducted in patient's homes. Linked health biodevices enabled high-resolution monitoring of lifestyle and physiological response.

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  • Advances in DNA sequencing technology have made it faster and more affordable, leading to improved data availability and the need for complex algorithms and workflows.
  • Metapipeline-DNA is a customizable and flexible analysis pipeline that handles various processing tasks like read alignment, variant calling, and quality control, making it easier to analyze DNA sequencing data.
  • This open-source tool is available under the GPLv2 license and can be accessed for free at https://github.com/uclahs-cds/metapipeline-DNA.
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Background: Localized prostate tumors show significant spatial heterogeneity, with regions of high-grade disease adjacent to lower grade disease. Consequently, prostate cancer biopsies are prone to sampling bias, potentially leading to underestimation of tumor grade. To study the clinical, epidemiologic, and molecular hallmarks of this phenomenon, we conducted a prospective study of grade upgrading: differences in detected prostate cancer grade between biopsy and surgery.

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Importance: Observational data have shown that postdiagnosis exercise is associated with reduced risk of prostate cancer death. The feasibility and tumor biological activity of exercise therapy is not known.

Objective: To identify recommended phase 2 dose of exercise therapy for patients with prostate cancer.

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Localized cutaneous neurofibromas (cNFs) are benign tumors that arise in the dermis of patients affected by neurofibromatosis type 1 syndrome. cNFs are benign lesions: they do not undergo malignant transformation or metastasize. Nevertheless, they can cover a significant proportion of the body, with some individuals developing hundreds to thousands of lesions.

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  • * This study analyzed rare genetic variants by combining data from 21 cohorts worldwide, involving over 5,000 severe cases and 571,000 controls.
  • * A significant finding showed that a rare harmful variant in the TLR7 gene greatly increases the risk of severe COVID-19, indicating that rare variants could offer valuable insights for understanding and treating the disease.
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  • Researchers evaluated the effectiveness of restriction spectrum imaging (RSI-MRI) as a biomarker for predicting upgrading in prostate cancer patients undergoing active surveillance (AS) biopsies.
  • The study involved men who received MRI scans and 30 different biomarkers, analyzing their potential to predict reclassification on subsequent biopsies from January 2016 to June 2019.
  • RSI-MRI outperformed other non-imaging biomarkers, showing the highest prediction accuracy (AUC = 0.84), indicating its potential to enhance decision-making in AS protocols.
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Replicative immortality is a hallmark of cancer, and can be achieved through telomere lengthening and maintenance. Although the role of telomere length in cancer has been well studied, its association to genomic features is less well known. Here, we report the telomere lengths of 392 localized prostate cancer tumours and characterize their relationship to genomic, transcriptomic and proteomic features.

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