Publications by authors named "Stefan Dinges"

Article Synopsis
  • This study investigates using intraoperative radiotherapy (IORT) as an additional boost for high-risk breast cancer patients, combined with standard external beam radiotherapy (EBRT), and aims to evaluate treatment outcomes and side effects.
  • The study, known as TARGIT BQR, included 1133 patients across 10 centers from 2011 to 2020, assessing both acute and long-term toxicity following the IORT boost delivered immediately after tumor removal.
  • Findings showed that the IORT boost is feasible and generally safe, with low rates of serious side effects; however, some patients experienced mild to moderate acute and chronic effects such as erythema and fibrosis.
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Purpose: To analyze long-term results of two multicenter prospective single-arm trials (ARO-2010-01 and ARO-2013-04) investigating adjuvant hypofractionated radiotherapy (HF) with simultaneous integrated boost (SIB) after breast-conserving surgery (BCS).

Methods: Eligible patients had histopathologically confirmed unifocal breast cancer planned for whole breast irradiation plus boost radiotherapy to the tumor bed. In both studies, a total dose of 40 Gy was applied to the whole breast and of 48 Gy to the tumor bed in 16 fractions of 2.

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Article Synopsis
  • Hypofractionated radiotherapy (HF RT) is becoming the standard for treating breast cancer, but its adoption has been slow, particularly for patients with lymph node involvement.
  • A study investigated how the updated German S3 guidelines in 2017 affected the use of HF RT and the enrollment of patients with lymph node involvement in a specific clinical trial (HYPOSIB).
  • Results indicated that the use of HF RT increased over time, especially in university hospitals, but generally low enrollment of patients with lymph node involvement persisted throughout the trial.
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Purpose: We report results of a multicenter prospective single-arm phase II trial (ARO-2013-04, NCT01948726) of moderately accelerated hypofractionated radiotherapy with a simultaneous integrated boost (SIB) in patients with breast cancer receiving adjuvant radiotherapy after breast-conserving surgery.

Methods: The eligibility criteria included unifocal breast cancer with an indication for adjuvant radiotherapy to the whole breast and boost radiotherapy to the tumor bed. The whole breast received a dose of 40 Gy and the tumor bed a total dose of 48 Gy in 16 fractions of 2.

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Purpose: To evaluate the feasibility of hypofractionation with SIB in all settings in Germany to prepare a multicenter treatment comparison.

Methods: Eligible patients had histopathologically confirmed breast cancer operated by BCS. Patients received WBI 40.

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In German speaking areas, in the scientific establishment which is occupied with medical ethics in the narrower and wider senses, a vehement discussion has developed as to whether or not medical practitioners must ultimately advocate that which is understood to be modern medical ethics. Against the background of this discussion, this article takes up a position on these questions, not only theoretically, but also with reference to the fields of practice of medical studies, hospitals, and the health system. The article presents the proposals of the Institute for Ethics and Law in Medicine (University of Vienna) for the evaluation and further development of the theme of ethics within the framework of the Medical Curriculum of Vienna (MCW).

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Objective: We evaluated the safety and efficacy of high dose rate (HDR) brachytherapy using Iridium-192 (Ir 192) and 3D conformal external beam radiotherapy in patients with localized prostate cancer.

Methods: A total of 444 patients with localized prostate cancer underwent combined radiotherapy with interstitial Ir 192 and 3D conformal external beam radiotherapy between December 1992 and March 2001. The 230 patients, treated between December 1992 and December 1997 were analyzed.

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