Publications by authors named "Stefan Craciun"

Article Synopsis
  • Increased blood-brain barrier (BBB) permeability, influenced by the protease tissue plasminogen activator (tPA), is linked to a higher susceptibility to seizures, prompting an investigation into the tPA pathway's role in seizure development.
  • In experiments with genetically modified mice, researchers found that different genetic deficiencies related to tPA and the neuroserpin inhibitor impacted seizure onset and progression, highlighting the importance of BBB integrity in this process.
  • The study reveals that signaling through PDGFRα in perivascular astrocytes is a key mechanism in regulating seizures and suggests that targeting this pathway may provide new strategies for seizure management.
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Methods for decoding movements from neural spike counts using adaptive filters often rely on minimizing the mean-squared error. However, for non-Gaussian distribution of errors, this approach is not optimal for performance. Therefore, rather than using probabilistic modeling, we propose an alternate non-parametric approach.

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Two of the most critical tasks when designing a portable wireless neural recording system are to limit power consumption and to efficiently use the limited bandwidth. It is known that for most wireless devices the majority of power is consumed by the wireless transmitter and it often represents the bottleneck of the overall design. This paper compares two compression techniques that take advantage of the sparseness of the neural spikes in neural recordings using an information theoretic formalism to enhance the well-established vector quantization (VQ) algorithm.

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A design challenge of portable wireless neural recording systems is the tradeoff between bandwidth and power consumption. This paper investigates the compression of neuronal recordings in real-time using a novel discriminating Linde-Buzo-Gray algorithm (DLBG) that preserves spike shapes while filtering background noise. The technique is implemented in a low power digital signal processor (DSP) which is capable of wirelessly transmitting raw neuronal recordings.

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