Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature.

Purpose: Mice carrying pathogenic variants in the microphthalmia transcription factor (Mitf) gene show structural and functional changes in the retina and retinal pigment epithelium. The purpose of this study was to assess the vascular changes in Mitf mice carrying pathogenic variants by determining their retinal vessel diameter.

Methods: Mice examined in this study were: B6-Mitf (n = 6), B6-Mitf /Mitf (n = 6) and C57BL/6J wild type mice (n = 6), all 3 months old.