Maternal hemoglobin drop in multiple pregnancy is associated with higher gestational age at birth and birthweight.

Introduction: This retrospective study investigated the hypothesis that maternal hemoglobin (Hb) levels in twin pregnancy fall between the first and second trimesters and that higher falls are associated with higher gestational age at birth and higher birthweight (BW).

Material And Methods: The study population was defined as pregnant women with twin pregnancies delivering two live, phenotypically normal neonates, after 24 weeks of gestation, between October 2009 and September 2021 at an inner London maternity unit. Maternal Hb and mean corpuscular volume (MCV), at ≤14 weeks of gestation (Hb1) and again at 20-30 weeks gestation (Hb2) were recorded from the Hospital's perinatal database.

Continued versus discontinued oxytocin stimulation in the active phase of labour (CONDISOX): individual management based on artificial intelligence - a secondary analysis.

Background: Current guidelines regarding oxytocin stimulation are not tailored to individuals as they are based on randomised controlled trials. The objective of the study was to develop an artificial intelligence (AI) model for individual prediction of the risk of caesarean delivery (CD) in women with a cervical dilatation of 6 cm after oxytocin stimulation for induced labour. The model included not only variables known when labour induction was initiated but also variables describing the course of the labour induction.

Planned cesarean delivery vs planned vaginal delivery: a systematic review and meta-analysis of randomized controlled trials.

Objective: There are over 145 million births worldwide, with over 30 million cesarean deliveries yearly. There are limited data comparing the perinatal and maternal outcomes between planned cesarean delivery and planned vaginal delivery. This study aimed to evaluate perinatal and maternal morbidity and mortality by meta-analysis of randomized controlled trials that randomly assigned patients to either planned cesarean delivery or planned vaginal delivery.

B-type natriuretic peptide in low-risk pregnancy and pregnancy with congenital heart disease.

Objective: To perform a longitudinal assessment of B-type natriuretic peptide (BNP) and its association with cardiac function in low-risk pregnant women and in pregnant women with congenital heart disease (CHD).

Methods: Longitudinal study in low-risk pregnancy and pregnancy in women with CHD seen at 10-14, 18-22, and 30-34 weeks of pregnancy for BNP quantification and exercise studies using impedance cardiography (ICG).

Results: Forty-three low-risk women with longitudinal samples (129 samples, 43 in each trimester) and 30 pregnant women with CHD with convenience samples (first trimester, five samples; second trimester, 20 samples; third trimester, 21 samples) were included.

Risk factors for a serious adverse outcome in neonates: a retrospective cohort study of vaginal births.

Objective: To investigate the hypothesis that risk factors in addition to an abnormal fetal heart rate pattern (aFHRp) are independently associated with adverse neonatal outcomes of labour.

Design: Observational prospective cohort study.

Setting: 17 UK maternity units.

Direct current cardioversion in pregnancy: a multicentre study.

Objective: Direct current cardioversion (DCCV) in pregnancy is rarely required and typically only documented in single case reports or case series. A recent UK confidential enquiry reported on several maternal deaths where appropriate DCCV appeared to have been withheld.

Design: Retrospective cohort study.

Revealing the hidden signature of fault slip history in the morphology of degrading scarps.

Active faults accommodate tectonic plate motion through different slip modes, some stable and aseismic, others characterized by the occurrence of large earthquakes after long periods of inactivity. Although the slip mode estimation is of primary importance to improve seismic hazard assessment, this parameter inferred today from geodetic observations needs to be better constrained over many seismic cycles. From an analytical formulation developed for analyzing fault scarp formation and degradation in loosely consolidated material, we show that the final topographic shape generated by one earthquake rupture or by creep (i.

Continued versus discontinued oxytocin stimulation in the active phase of induced labour: Factors associated with unexpectedly high rates of conversion to open label oxytocin in the CONDISOX trial.

Objective: To examine the factors associated with unexpectedly high rates of conversion to open label oxytocin in the CONDISOX trial of continuation versus discontinuation of oxytocin infusion during induced labour.

Design: Secondary retrospective analysis of data from a prospective randomised controlled trial.

Setting: Nine hospitals in Denmark and one in the Netherlands between 8 April 2016 and 30 June 2020.

A case-control study of the interaction of fetal heart rate abnormalities, fetal growth restriction, meconium in the amniotic fluid and tachysystole, in relation to the outcome of labour.

Objective: To quantify the incidence of intrapartum risk factors in labours with an adverse outcome, and compare them with the incidence of the same indicators in a series of consecutive labours without adverse outcome.

Design: Case-control study.

Setting: Twenty-six maternity units in the UK.

Screening for late-onset gestational diabetes: Are there any clinical benefits?

Objective: To determine whether screening for gestational diabetes mellitus (GDM) in the third trimester and managing those who are screen positive on a diabetes pathway affects obstetric and neonatal outcomes.

Design: Retrospective study of prospectively collected data.

Setting: London Teaching Hospital.

Maternal and fetal outcomes in women with cerebrovascular malformations in pregnancy: A multicentre retrospective cohort study.

Objective: To determine maternal, obstetric and neonatal outcomes in a cohort of women with cerebrovascular malformations (CVMs) that include arterial venous malformations (AVMs) and cavernomas.

Design: Retrospective cohort study.

Setting: Six specialist centres managing pregnant women with neurological disorders.

Pregnancies in women with Turner syndrome: a retrospective multicentre UK study.

Objective: To determine the characteristics and outcomes of pregnancy in women with Turner syndrome.

Design: Retrospective 20-year cohort study (2000-20).

Setting: Sixteen tertiary referral maternity units in the UK.

The effect of mode of delivery and duration of labour on subsequent pregnancy outcomes: a retrospective cohort study.

Objective: To assess whether delivery mode and duration of labour in a first labour of spontaneous onset is associated with gestational length, delivery mode and neonatal outcome in the subsequent pregnancy.

Study Design: Retrospective analysis of prospectively collected data.

Setting: 15 Maternity units in North West London (1988-2000).

Mechanical heart valves and pregnancy: Issues surrounding anticoagulation. Experience from two obstetric cardiac centres.

Background: Pregnant women with mechanical heart valves are at significant risk of obstetric/cardiac complications. This study compares the anticoagulation management in two obstetric cardiac centres.

Methods: Retrospective case-note review from Chelsea and Westminster/Royal Brompton Hospitals (CR) and Erasmus Medical Centre (EMC).

Seasonal and SARS-CoV-2 pandemic changes in the incidence of gestational diabetes.

Objective: To test the hypothesis that there is seasonal variation in the rates of gestational diabetes (GDM) diagnosed using a 2-hour oral glucose tolerance test.

Design: Monthly assessment of the percentage of women screened from 1 April 2016 to the 31 December 2020 who were diagnosed as having gestational diabetes.

Setting: London teaching hospital.