Hyperpolarized [1-C]pyruvate cardiovascular magnetic resonance imaging identifies metabolic phenotypes in patients with heart failure.

Background: Hyperpolarized [1-C]pyruvate cardiovascular magnetic resonance imaging (HP [1-C]pyruvate CMR) visualizes key steps in myocardial metabolism. The present study aimed to examine patients with heart failure (HF) using HP [1-C]pyruvate CMR.

Methods: A cross-sectional study of patients with HF and healthy controls using HP [1-C]pyruvate CMR.

Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-C]pyruvate cardiovascular magnetic resonance imaging.

Background: Hyperpolarized (HP) [1-C]pyruvate cardiovascular magnetic resonance (CMR) imaging can visualize the uptake and intracellular conversion of [1-C]pyruvate to either [1-C]lactate or C-bicarbonate depending on the prevailing metabolic state. The aim of the present study was to combine an adenosine stress test with HP [1-C]pyruvate CMR to detect cardiac metabolism in the healthy human heart at rest and during moderate stress.

Methods: A prospective descriptive study was performed between October 2019 and August 2020.