AEDEOMYIA SQUAMIPENNIS: A NEW GENUS AND SPECIES RECORD FOR COLLIER COUNTY, FLORIDA, USA.

On November 7, 2023, 3 female specimens of Aedeomyia squamipennis were captured in Collier County, Florida, for the first time during routine adult mosquito surveillance in Collier Seminole State Park. This species was first found in the USA in Miami-Dade County in 2016 and has since expanded into multiple counties throughout South Florida. The presence of Ad.

Impact of Angiotensin Converting Enzyme Inhibitors on Pathologic Complete Response With Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer.

Introduction: The renin-angiotensin system (RAS) has been demonstrated to modulate cell proliferation, desmoplasia, angiogenesis and immunosuppression. We examined the association of RAS inhibitors (RASi)-namely angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB)-with neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer (MIBC) preceding radical cystectomy (RC).

Patients And Methods: We retrospectively investigated concurrent RASi use with NAC prior to RC in 302 patients with MIBC from 3 academic institutions.

A qualitative approach to understanding the drivers of unequal receipt of definitive therapy for Black men with prostate cancer in Massachusetts.

Background: Despite mandated insurance coverage since 2006 and robust health infrastructure in urban settings with high concentrations of minority patients, race-based disparities in prostate cancer (PCa) treatment persist in Massachusetts. In this qualitative study, the authors sought to identify factors driving inequities in PCa treatment in Massachusetts.

Methods: Four hospitals offering PCa treatment in Massachusetts were selected using a case-mix approach.

Photon Pressure with an Effective Negative Mass Microwave Mode.

Harmonic oscillators belong to the most fundamental concepts in physics and are central to many current research fields such as circuit QED, cavity optomechanics, and photon pressure systems. Here, we engineer a microwave mode in a superconducting LC circuit that mimics the dynamics of a negative mass oscillator, and couple it via photon pressure to a second low-frequency circuit. We demonstrate that the effective negative mass dynamics lead to an inversion of dynamical backaction and to sideband cooling of the low-frequency circuit by a blue-detuned pump field, which can be intuitively understood by the inverted energy ladder of a negative mass oscillator.

Resolving Nonperturbative Renormalization of a Microwave-Dressed Weakly Anharmonic Superconducting Qubit Coupled to a Single Quantized Mode.

Microwave driving is a ubiquitous technique for superconducting qubits, but the dressed states description based on the conventionally used perturbation theory cannot fully capture the dynamics in the strong driving limit. Comprehensive studies beyond these approximations applicable to transmon-based circuit quantum electrodynamics (QED) systems are unfortunately rare, as the relevant works have been mainly limited to single-mode or two-state systems. In this work, we investigate a microwave-dressed transmon coupled to a single quantized mode over a wide range of driving parameters.

Apparent nonlinear damping triggered by quantum fluctuations.

Nonlinear damping, the change in damping rate with the amplitude of oscillations plays an important role in many electrical, mechanical and even biological oscillators. In novel technologies such as carbon nanotubes, graphene membranes or superconducting resonators, the origin of nonlinear damping is sometimes unclear. This presents a problem, as the damping rate is a key figure of merit in the application of these systems to extremely precise sensors or quantum computers.

Anticoagulation prophylaxis patterns following retroperitoneal lymph node dissection for testis cancer.

Introduction: Retroperitoneal lymph node dissection (RPLND) is the standard of care for testicular cancer in various disease settings. Deep vein thrombosis (DVT) complications have been reported to occur in <1% of primary RPLND cases and up to 3% of postchemotherapy (PC-RPLND) cases. While prophylactic anticoagulation (AC) has been well-documented to reduce DVT rates in patients undergoing surgery in general, the benefit of prophylactic AC in RPLND has not been assessed.

Evidence-Based Analysis of the Critical Steps of Radical Cystectomy for Bladder Cancer.

Radical cystectomy (RC) is an integral part of the management of patients with advanced-stage bladder cancer. This major oncologic operation is prone to complications resulting in morbidity and mortality. We analyzed the critical steps of open RC, performed an evidence-based review of these steps, and discussed our experience and approach.

Safety and tolerability of tedizolid as oral treatment for bone and joint infections.

Bone and joint infections (BJIs) are common infections increasingly managed with oral therapy. However, there are limited safe oral options for many Gram-positive pathogens. In animal studies and short-term human use, tedizolid lacks the hematologic and neurologic toxicity of the other available oxazolidinone, linezolid.

Racial differences in patient-reported outcomes among men treated with radical prostatectomy for prostate cancer.

Background: Real-world data on racial differences in the side effects of radical prostatectomy on quality of life (QoL) are lacking. We aimed to evaluate differences in patient-reported outcome measure (PROM) among non-Hispanic Black (NHB) and non-Hispanic White (NHW) men using the Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) questionnaire to measure health-related QoL after radical prostatectomy.

Methods: We retrospectively assessed prospectively collected PROMs using EPIC-CP scores at a tertiary care center between 2015 and 2021 for men with prostate cancer undergoing radical prostatectomy.

Sequential intravesical gemcitabine/docetaxel provides a durable remission in recurrent high-risk NMIBC following BCG therapy.

Purpose: Bacillus Calmette-Guerin (BCG) is the standard of care for high-risk nonmuscle invasive bladder cancer (NMIBC), but half of patients develop disease recurrence. Intravesical regimens for BCG unresponsive NMIBC are limited. We report the safety, efficacy, and differential response of sequential gemcitabine/docetaxel (gem/doce) depending on BCG failure classification.

Dalbavancin vs standard of care for Staphylococcus aureus bacteraemia in patients unable to receive outpatient parenteral antimicrobial therapy.

Background: This study compared dalbavancin with standard of care (SOC) for patients with Staphylococcus aureus bacteraemia (SAB) who were unable to receive outpatient parenteral antimicrobial therapy (OPAT).

Methods: This retrospective cohort compared re-admission rates related to the index infection between patients treated with dalbavancin or SOC for SAB. Patients aged ≥18 years seen by the infectious diseases consult service who had received at least one dose of dalbavancin or at least 1 week of SOC parenteral antibacterials as directed therapy for SAB at the time of discharge were included.

Designing spin and orbital sources of Berry curvature at oxide interfaces.

Quantum materials can display physical phenomena rooted in the geometry of electronic wavefunctions. The corresponding geometric tensor is characterized by an emergent field known as the Berry curvature (BC). Large BCs typically arise when electronic states with different spin, orbital or sublattice quantum numbers hybridize at finite crystal momentum.

Staphylococcus Epidermidis as a Uropathogen in Children.

Historically, Staphylococcus epidermidis has been considered a contaminant when grown on urine cultures. However, a growing body of literature suggests that S. epidermidis can cause urinary tract infections (UTIs) in children with anatomic variants or a history of instrumentation.

Impact of exercise on physical health status in bladder cancer patients.

Introduction: There is a scarcity of data on the impact of behavioral habits, such as exercise, on physical health in patients with bladder cancer. We investigated the association of exercise on self-reported physical health status and examined the prevalence of bladder cancer patients with sedentary lifestyle.

Methods: We examined cross-sectional data of participants diagnosed with bladder cancer within the Behavioral Risk Factor Surveillance System (BRFSS) from 2016-2020.

Parametrically enhanced interactions and nonreciprocal bath dynamics in a photon-pressure Kerr amplifier.

Photon-pressure coupling between two superconducting circuits is a promising platform for investigating radiation-pressure coupling in distinct parameter regimes and for the development of radio-frequency (RF) quantum photonics and quantum-limited RF sensing. Here, we implement photon-pressure coupling between two superconducting circuits, one of which can be operated as a parametric amplifier. We demonstrate a Kerr-based enhancement of the photon-pressure single-photon coupling rate and an increase of the cooperativity by one order of magnitude in the amplifier regime.

Acceleration and deceleration of quantum dynamics based on inter-trajectory travel with fast-forward scaling theory.

Quantum information processing requires fast manipulations of quantum systems in order to overcome dissipative effects. We propose a method to accelerate quantum dynamics and obtain a target state in a shorter time relative to unmodified dynamics, and apply the theory to a system consisting of two linearly coupled qubits. We extend the technique to accelerate quantum adiabatic evolution in order to rapidly generate a desired target state, thereby realizing a shortcut to adiabaticity.

Missed opportunities to identify cryptococcosis in COVID-19 patients: a case report and literature review.

SARS-CoV-2 may activate both innate and adaptive immune responses ultimately leading to a dysregulated immune response prompting the use of immunomodulatory therapy. Although viral pneumonia increases the risk of invasive fungal infections, it remains unclear whether SARS-CoV-2 infection, immunomodulatory therapy, or a combination of both are responsible for the increased recognition of opportunistic infections in COVID-19 patients. Cases of cryptococcosis have previously been reported following treatment with corticosteroids, interleukin (IL)-6 inhibitors, and Janus kinase (JAK) inhibitors, for patients with autoimmune diseases, but their effect on the immunologic response in patients with COVID-19 remains unknown.

Cooling photon-pressure circuits into the quantum regime.

Quantum control of electromagnetic fields was initially established in the optical domain and has been advanced to lower frequencies in the gigahertz range during the past decades extending quantum photonics to broader frequency regimes. In standard cryogenic systems, however, thermal decoherence prevents access to the quantum regime for photon frequencies below the gigahertz domain. Here, we engineer two superconducting circuits coupled by a photon-pressure interaction and demonstrate sideband cooling of a hot radio frequency (RF) circuit using a microwave cavity.

Critical current fluctuations in graphene Josephson junctions.

We have studied 1/f noise in critical current [Formula: see text] in h-BN encapsulated monolayer graphene contacted by NbTiN electrodes. The sample is close to diffusive limit and the switching supercurrent with hysteresis at Dirac point amounts to [Formula: see text] nA. The low frequency noise in the superconducting state is measured by tracking the variation in magnitude and phase of a reflection carrier signal [Formula: see text] at 600-650 MHz.

Feasibility and Limitations of Proning Protocol for Nonintubated Patients With COVID-19.

Proning awake patients with COVID-19 is associated with lower mortality and intubation rates. However, these studies also demonstrate low participation rates and tolerance of awake proning. In this study, we attempt to understand barriers to proning.

An economic analysis comparing health care resource use and cost of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin versus gemcitabine and cisplatin as neoadjuvant therapy for muscle invasive bladder cancer.

Purpose: To compare healthcare resource utilization (HRU) and costs associated with dose-dense methotrexate, vinblastine, doxorubicin, cisplatin (ddMVAC) and gemcitabine, cisplatin (GC) as neoadjuvant chemotherapy for muscle-invasive bladder cancer (MIBC).

Methods: Patient treated at Dana-Farber Cancer Institute from 2010 to 2019 were identified. HRU data on chemotherapy administered, supportive medications, patient monitoring, clinic, infusion, emergency department (ED) visits and hospitalization were collected retrospectively.