Phagosomal granulocytic ROS in septic patients induce the bacterial SOS response.

Septic patients with worst clinical prognosis have increased circulating immature granulocytes (IG), displaying limited phagocytosis and reactive oxygen species (ROS) production. Here, we developed an model of incubation of human granulocytes, from septic patients or healthy donors, with . We showed that the ROS production in Sepsis-IG is lower due to decreased activation and protein expression of the NADPH oxidase complex.