Antibodies to Berne virus in horses and other animals.

After inoculation into 2 foals, Berne virus induced neutralizing antibody, but did not cause clinical symptoms. In a horizontal study of seropositive mares and their offspring, a decline of maternal antibodies and a sudden synchronous seroconversion in all foals were observed, again without clinical symptoms. The virus is widespread in the Swiss horse population and has been so during the last decade; rises in antibody titers were noted in 9% of paired sera sampled at random.

Purification and partial characterization of a new enveloped RNA virus (Berne virus).

In Berne (Switzerland), a virus was isolated from a horse which was found to be serologically unrelated to known equine viruses. Its growth was unaffected by iododeoxyuridine and it was inactivated by organic solvents. A purification procedure involving ammonium sulphate precipitation and sucrose gradient equilibrium centrifugation was developed and viral activities were monitored using infectivity and enzyme-linked immunosorbent assays.

Small mammal studies in a SAD baiting area.

Studies in the laboratory or in the field on the effect of SAD virus on small rodents are reported. Laboratory experiments by oral inoculation of SAD strain in a wide variety of small mammals led to the conclusion that spontaneous SAD transmission from rodent to rodent is a rare event. Field experiments were conducted by live-trapping, sacrifice and analysis of 192 Apodemus sylvaticus, 28 Clethrionomys glareolus and 48 Crocidura russula.

Oral immunization of foxes against rabies. Laboratory and field studies.

A short description is given of the laboratory experience gained in oral immunization of foxes against rabies, and its application in a limited field trial in Switzerland with an attempt to control two outbreaks of fox rabies.

Assessment of fox control in areas of wildlife rabies.

This paper describes a technique for the analysis of the interaction between rabies control measures and the annual turnover of a fox population. The basic conditions are deduced from data on the turnover of a steady fox population, which have been found to be representative for large parts of central Europe. These conditions, together with field data on the critical density for rabies transmission and the recovery of reduced fox populations, provide a model for the prediction and evaluation of various measures of rabies control.

Comparison of the genomes of infectious bovine rhinotracheitis and infectious pustular vulvovaginitis virus strains by restriction endonuclease analysis.

Differences could be detected between Infections bovine rhinotracheitis (IBR) and Infectious pustular vulvovaginitis (IPV) virus strains by restriction enzyme analysis of their genomes.

Everglades virus infection in man, 1975.

Within 72 hours of visiting the Everglades National Park in south Florida, a 43-year-old man became ill with fever, malaise, myalgia, severe headache, pharyngitis, and enlarged, tender lymph nodes. Everglades (Venezuelan equine encephalomyelitis, subtype II) virus was isolated from a blood sample drawn from the patient five days after onset of symptoms.

[Rabies in a veterinarian].

A 57-year-old veterinary surgeon developed rabies 174 days after injury during an oral palpation of a rabid cow. He had been vaccinated prophylactically with Duck embryo vaccine several months before exposure but never had his serum antibody level controlled. He died 45 days later.

[The re-emergence of human rabies in Switzerland. A case history].

The circumstances, clinical symptoms, and outcome of a case of human rabies are reported. The disease was conveyed by a housecat. Since the report gave no cause for concern, antirabies vaccination was not considered to be necessary.

[Epidemiology of rabies (author's transl)].

Rabies is widespread in all continents except Australia. As an anthropozoonosis its main importance is in areas with uncontrolled dog rabies, nowadays principally topical and subtropical regions. The greatest economic losses however are encountered in the cattle herds of South and Central America, where paralyssa prevails.

Humoral immunity conferred by the HDCS rabies vaccine Mérieux administered after exposure: 151 cases with and without specific immune globulin of human origin. Preliminary communication.

The results of the analysis of the neutralizing antibodies measured at days 30 and 90 after vaccination are described in brief. Different lots of Mérieux vaccine were used, of which two were checked separately for relative antigenic value by the Federal Public Health Service (CH). The lowest antigenic value (lot 0420 M) was 1.

IgM and IgG antibody profiles after immunization of man with a HDCS-vaccine (preliminary communication).

HDCS vaccine was given to 20 healthy, not rabies-exposed people on days 0, 3, 7, 14, 28 and 90. Ten of them received in addition 20 IU/kg of human antirabies immunoglobulin. Vaccine potency in NIH tests was 1.