Publications by authors named "Stavroula Tsaridou"
DNA repair through homologous recombination (HR) is of vital importance for maintaining genome stability and preventing tumorigenesis. RAD51 is the core component of HR, catalyzing the strand invasion and homology search. Here, we highlight recent findings on FIRRM and FIGNL1 as regulators of the dynamics of RAD51.
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- Joint DNA molecules from DNA replication and repair can lead to ultrafine DNA bridges (UFBs) during mitosis, which hinder sister chromatid separation.
- The study highlights the importance of PICH, a DNA translocase, in resolving UFBs and identifies FIRRM as a key regulator that interacts with FIGNL1, an ATPase involved in DNA processes.
- Inhibition of FIRRM or FIGNL1 causes UFBs to form and disrupts RAD51 dynamics at replication forks, leading to DNA damage and reliance on PICH for cell survival.
Article Synopsis
- DNA lesions are damages in the genetic material that can harm cells, but some specific areas, like ribosomal RNA genes (rDNA), are especially vulnerable.
- A protein called RASSF1A helps fix these rDNA damages and is important for keeping the cell's DNA stable.
- When RASSF1A is not working properly, it can lead to more DNA breaks and problems in cells, contributing to diseases like cancer.
Cell differentiation is a process that must be precisely regulated for the maintenance of tissue homeostasis. Differentiation towards a multiciliated cell fate is characterized by well-defined stages, where a transcriptional cascade is activated leading to the formation of multiple centrioles and cilia. Centrioles migrate and dock to the apical cell surface and, acting as basal bodies, give rise to multiple motile cilia.
View Article and Find Full Text PDFHuman brain possesses a unique anatomy and physiology. For centuries, methodological barriers and ethical challenges in accessing human brain tissues have restricted researchers into using 2-D cell culture systems and model organisms as a tool for investigating the mechanisms underlying neurological disorders in humans. However, our understanding regarding the human brain development and diseases has been recently extended due to the generation of 3D brain organoids, grown from human stem cells or induced pluripotent stem cells (iPSCs).
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