Publications by authors named "Stasys Auskalnis"
Article Synopsis
- * A 36-year-old patient had both tumors, leading to the removal of a large testicular mass and subsequent surgeries for kidney and adrenal tumors, ultimately diagnosed through histological evaluations.
- * After initial treatment with chemotherapy, the patient experienced progressive metastasis, prompting targeted therapy, indicating a genetic predisposition to having multiple primary tumors, which could be better understood through DNA sequencing.
Background: Teverelix drug product (DP) is a novel injectable gonadotropin-releasing hormone antagonist.
Methods: An adaptive phase 2, open-label, multicenter trial was conducted in patients with advanced prostate cancer to evaluate the efficacy and safety of a combined subcutaneous (SC) and intramuscular (IM) loading dose regimen of teverelix DP of 120 mg SC + 120 mg IM (Group 1; N = 9) or 180 mg SC + 180 mg IM (Group 2; N = 41) administered at a single visit, followed by 6-weekly SC maintenance doses of 120 mg (Group 1) or 180 mg (Group 2), up to Day 168. The primary endpoint was the proportion of patients achieving castration levels with serum testosterone <0.
Article Synopsis
- The study analyzed factors predicting prostate-cancer-specific mortality (CSM) after radical prostatectomy in 2,421 men between 2001-2017.
- Findings revealed that 2.3% of deaths during an average 8-year follow-up were due to prostate cancer, with significant predictors of CSM being high-grade tumors, lymph node invasion, advanced cancer stage, and older age.
- The research concluded that understanding these predictors could help doctors identify high-risk patients who may need more aggressive treatment approaches.
Article Synopsis
- The study explores how the 2014 ISUP grading system relates to biochemical recurrence (BCR), clinical progression (CP), and cancer-related death (CRD) in men after open radical prostatectomy (RP).
- An analysis of 1,754 men revealed that grade group 5 had the poorest survival rates, while grade groups 3 and 4 showed similar long-term disease progression outcomes.
- The ISUP grading system was identified as a crucial independent factor for predicting BCR, CP, and CRD, with pathological stage and surgical margins also playing significant roles.
Purpose: High-grade prostatic intraepithelial neoplasia (HGPIN) is a potential precursor of prostate cancer (PCa), and patients with HGPIN are at high risk for PCa development. Objective of our study was to evaluate the efficacy of dutasteride 0.5 mg in PCa prevention among men with isolated HGPIN on biopsy.
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- The study compared long-term outcomes of nephron-sparing surgery (NSS) and radical nephrectomy (RN) for renal cell carcinoma (RCC) tumors between 4 to 7 cm in size, analyzing data from 1998 to 2009.
- Out of 351 patients, most underwent RN (90.3%), with 12-year cancer-specific survival rates at 69.6% for RN and 80.6% for NSS, indicating no significant survival difference between the groups.
- The findings suggest that NSS is a safe and effective option for treating RCC in this size range, and it may be favored over RN, which was previously preferred for tumors larger than 4 cm.
Unlabelled: The objective of the study was to evaluate the relationship between high-grade intraepithelial neoplasia diagnosed after radical retropubic prostatectomy and the clinical and pathological characteristics of prostate cancer, and to evaluate the time to biochemical relapse of the disease within the groups of high-grade prostatic intraepithelial neoplasia (HGPIN) and non-HGPIN patients.
Material And Methods: Patients, clinically diagnosed with local prostate carcinoma at the Clinic of Urology, Kaunas University of Medicine, during 2003-2007 and treated with radical retropubic prostatectomies, were distributed into two groups according to the HGPIN detected in the postoperative material: HGPIN and non-HGPIN. The two groups were compared in terms of preoperative and postoperative characteristics.
Introduction: The aim of this study is to present the oncologic outcomes and to determine prognostic parameters of overall (OS), cancer specific survival (CSS), disease progression free survival (DPFS) and biochemical progression free survival (BPFS) after surgery for pT3a prostate cancer (PCa).
Material And Methods: Between 2002 and 2007, a pT3a stage after radical prostatectomy was detected in 126 patients at our institution. Kaplan-Meier analysis was used to calculate OS, CSS, DPFS and BPFS.
Article Synopsis
- Prostate cancer with a Gleason score of 6 is common in biopsies, and this study aimed to understand why some tumors are graded higher after surgery.
- The research involved 241 patients who had surgery for Gleason score 6 cancer, analyzing various clinical factors to see what might predict an upgrade in Gleason score.
- Results showed that about 38.2% of patients had their scores upgraded after surgery, with prostate weight and PSA density being significant predictors of this upgrade along with increased risk of more serious cancer features.
Unlabelled: Our purpose was to evaluate the relevance of repeat laterally directed sextant prostate biopsy for detection of prostate cancer in high-risk patients.
Material And Methods: Our study included 195 men at high risk for prostate cancer (elevated prostate-specific antigen level and/or abnormal prostate detected by digital rectal examination). We consulted the patients in outpatient department of Kaunas University of Medicine Hospital during 2003-2007.
Unlabelled: The aim of this study was to evaluate the relevance of prostate gland volume, transitional zone volume, and transitional zone index for the detection of prostate cancer by the first sextant biopsy.
Material And Methods: A total of 121 men with high risk of prostate cancer were included in our study (prostate-specific antigen level higher than 4 ng/mL and/or pathological digital rectal examination). We consulted the patients in Outpatient Department of Kaunas University of Medicine Hospital during 2003-2006.
A rare case of primary peritonitis caused by group A beta-hemolytic streptococcus in previously healthy woman is presented. The entry site of infection was tonsillitis. Infection was complicated by soft-tissue infection of abdominal and thoracic wall, associated with toxic shock.
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