[Biochemical mechanisms of neurotoxic reactions to antibacterial preparations in patients with pulmonary tuberculosis].

Examination comprising the electrophysiologic method and study of the biochemical parameters of the antioxidant/lipid peroxidation system and metabolism of biologic amines in 163 patients with infiltrative pulmonary tuberculosis has revealed a clear interaction existing between the functional changes of the CNS state, the state of antioxidative defense (alpha-tocopherol) and serotonin. This allows an assumption that the antioxidant/lipid peroxidation system and serotoninergic system actively participate in the pathogenesis of development of neurotoxic reactions to antibacterial preparations in the clinical picture of tuberculosis.

[The use of antioxidants in the complex therapy of patients with infiltrating pulmonary tuberculosis].

Clinical and laboratory investigations examined the possibility of a lower load of antibacterial drugs (ABD) in combination with the two antioxidants, alpha-tocopherol and sodium thiosulfate, in combined therapy of patients with infiltrative pulmonary tuberculosis. Higher efficacy of two ABDs supplemented by two antioxidants than three or more ABDs was evidenced by a shorter period of sputum negativity (1.6 +/- 0.

[Functional disorders of the central nervous system in patients with pulmonary tuberculosis].

Two groups of pulmonary tuberculosis patients were followed up to reveal the relation between the lipid peroxidation (LPO) processes and the function of the central nervous system (CNS) in pulmonary tuberculosis. Group 1 (n = 76) included subjects with normal baseline electroencephalographic findings; group 2 (n = 41) consisted of those with profound changes in the electroencephalogram. The findings of LPO processes were assessed by the blood levels of malonic dialdehyde and alpha-tocopherol.

[Pathogenetic therapy in pulmonary tuberculosis].

Clinico-biochemical comparisons with an account of the peculiar characteristics of the tuberculosis process showed that it was advisable to use antioxidants as antifibrotic pathogenetic agents. The most pronounced effect was observed when combinations of two antioxidants or one antioxidant with lidase were applied.

[Indications for the use of prednisolone in tuberculosis].

To study the nature of lesions in the lungs developing as a result of using glucocorticoids in combined therapy of tuberculosis, two groups of new cases of infiltrative tuberculosis were observed. 51 patients were treated with the use of prednisolone and 23 patients were treated with antibacterial drugs alone. In addition, studies were performed on two groups of noninbred albino rats infected with mycobacteria Bovinus-8.

[Antioxidants--effective pathogenetic agents in the combined therapy of pulmonary tuberculosis].

The use of anti-oxidants (alpha-tocopherol and sodium thiosulphate in multimodality therapy of patients with infiltrative pulmonary tuberculosis raised therapeutic efficacy promoting elimination of signs of tuberculous intoxication, the onset of bacteria elimination, disintegration cavity closing, and a decrease in the frequency of residual changes. The advantage of alpha-tocopherol was shown in its administration to patients with infiltrative tuberculosis with the prevailing productive tissue reactions. alpha-tocopherol prevented the occurrence of noticeable respiratory insufficiency contributing to its elimination in patients with fibrocavernous tuberculosis.