Quantifying spectral information about source separation in multisource odour plumes.

Odours released by objects in natural environments can contain information about their spatial locations. In particular, the correlation of odour concentration timeseries produced by two spatially separated sources contains information about the distance between the sources. For example, mice are able to distinguish correlated and anti-correlated odour fluctuations at frequencies up to 40 Hz, while insect olfactory receptor neurons can resolve fluctuations exceeding 100 Hz.

Repair of Microperforate Hymen.

Objective: Subocclusive variants of the hymen are a group of hymenal anomalies that result due to a failure of canalization of the urogenital sinus. One of these variations is the microperforate hymen, for which accurate incidence is unknown. Microperforate hymen is a non-obstructing variation that allows for menstrual egress and often patients present due to inability to use a tampon.

Effects of magnetically treated water on the survival of bacteria in biofilms.

The goal of this study was to evaluate if a magnetic water treatment device could be used to mitigate biofilms in water systems. Magnetic treatment was applied to water upstream of a modified Robbins device in which biofilms were formed. Duration of magnetic treatment, system flow rate, and field strength were varied to assess the impacts on the biofilm.

Toward the validation of crowdsourced experiments for lightness perception.

Crowdsource platforms have been used to study a range of perceptual stimuli such as the graphical perception of scatterplots and various aspects of human color perception. Given the lack of control over a crowdsourced participant's experimental setup, there are valid concerns on the use of crowdsourcing for color studies as the perception of the stimuli is highly dependent on the stimulus presentation. Here, we propose that the error due to a crowdsourced experimental design can be effectively averaged out because the crowdsourced experiment can be accommodated by the Thurstonian model as the convolution of two normal distributions, one that is perceptual in nature and one that captures the error due to variability in stimulus presentation.

Concurrent processing of the prosodic hierarchy is supported by cortical entrainment and phase-amplitude coupling.

Models of phonology posit a hierarchy of prosodic units that is relatively independent from syntactic structure, requiring its own parsing. It remains unexplored how this prosodic hierarchy is represented in the brain. We investigated this foundational question by means of an electroencephalography (EEG) study.

Different measures of ventilatory efficiency in preoperative cardiopulmonary exercise testing are useful for predicting postoperative complications in abdominal cancer surgery.

Background: Ventilation as a function of elimination of CO during incremental exercise (VE/VCO slope) has been shown to be a valuable predictor of complications and death after major non-cardiac surgery. VE/VCO slope and partial pressure of end-tidal carbon dioxide (PetCO) are both affected by ventilation/perfusion mismatch, but research on the utility of PetCO for risk stratification in major abdominal surgery is limited.

Aim: We aimed to determine the correlation between VE/VCO slope and PetCO measured during preoperative cardiopulmonary exercise testing (CPET) and its association with major cardiopulmonary complications (MCPCs) or death following oesophageal and other major abdominal cancer surgeries.

A multicenter cohort study analysing the implementation of a new guideline for women with pregnancy of unknown location or ectopic pregnancy in the Netherlands.

Objective: Evaluation of the implementation of a new guideline for diagnosis and treatment of women with pregnancy of unknown location (PUL) or ectopic pregnancy (EP).

Design: Multicenter retrospective cohort study.

Setting: Six hospitals in the Northern part of the Netherlands.

Universal Crisis Information Design: A Multi-Case Study.

This paper presents a multi-case study on universal crisis information design, focusing on individuals with communication disorders, the elderly, and immigrants. Using a research-through-design approach and various qualitative data collection methods, the study explores accessible information solutions by examining the accessibility of crisis information design and developing universal crisis information design guidelines based on the findings. The findings highlight the necessity for simplified crisis messages, multimodal communication, and the involvement of community facilitators.

A Real-Life Laboratory Setting for Clinical Practice, Education, and Research in Family Systems Care: Protocol for a Transformational Action Research Study.

Background: Burdening health and illness issues such as physical or mental illnesses, accidents, disabilities, and life events such as birth or death influence the health and functioning of families and contribute to the complexity of care and health care costs. Considerable research has confirmed the benefits of a family systems-centered care approach for patients, family caregivers, families, and health care professionals. However, health care professionals face barriers in working with families, such as feeling unprepared.

Specificity of Episodic Future Thinking in Adolescents: Comparing Childhood Maltreatment, Autism Spectrum, and Typical Development.

Maltreatment and autism can be associated with overlapping difficulties across functional domains (e.g., social, emotional, and sensory) and high rates of mental health problems.

A scoping review on active vs. passive range of motion approaches to treat heterotopic ossification at the elbow.

Objective: The objective of this scoping review is to synthesize and clarify literature on the effectiveness of active and passive range of motion therapy techniques to address range of motion in people with heterotopic ossification (HO), and to provide guidance to therapists in clinical decision-making based on current evidence.

Method: To find articles that included therapeutic interventions to maintain or improve range of motion in people with heterotopic ossification, the authors searched the following databases: Cochrane Database of Systematic Reviews, PubMed, CINAHL, PsychINFO, Web of Science, and OTSeeker. To ensure that the search was comprehensive, the authors also searched Burns and Trauma, Burns Journal, Burns Open, and the Journal of Hand Therapy.

Learning to learn: Single session acquisition of new rules by freely moving mice.

Learning from examples and adapting to new circumstances are fundamental attributes of human cognition. However, it is unclear what conditions allow for fast and successful learning, especially in nonhuman subjects. To determine how rapidly freely moving mice can learn a new discrimination criterion (DC), we design a two-alternative forced-choice visual discrimination paradigm in which the DCs governing the task can change between sessions.

Local activation of CA1 pyramidal cells induces theta-phase precession.

Hippocampal theta-phase precession is involved in spatiotemporal coding and in generating multineural spike sequences, but how precession originates remains unresolved. To determine whether precession can be generated directly in hippocampal area CA1 and disambiguate multiple competing mechanisms, we used closed-loop optogenetics to impose artificial place fields in pyramidal cells of mice running on a linear track. More than one-third of the CA1 artificial fields exhibited synthetic precession that persisted for a full theta cycle.

Wired together, change together: Spike timing modifies transmission in converging assemblies.

The precise timing of neuronal spikes may lead to changes in synaptic connectivity and is thought to be crucial for learning and memory. However, the effect of spike timing on neuronal connectivity in the intact brain remains unknown. Using closed-loop optogenetic stimulation in CA1 of freely moving mice, we generated unique spike patterns between presynaptic pyramidal cells (PYRs) and postsynaptic parvalbumin (PV)-immunoreactive cells.

Machine learning-directed electrical impedance tomography to predict metabolically vulnerable plaques.

The characterization of atherosclerotic plaques to predict their vulnerability to rupture remains a diagnostic challenge. Despite existing imaging modalities, none have proven their abilities to identify metabolically active oxidized low-density lipoprotein (oxLDL), a marker of plaque vulnerability. To this end, we developed a machine learning-directed electrochemical impedance spectroscopy (EIS) platform to analyze oxLDL-rich plaques, with immunohistology serving as the ground truth.

In vivo optogenetic identification and manipulation of GABAergic interneuron subtypes.

Identification and manipulation of different GABAergic interneuron classes in the behaving animal are important to understand their role in circuit dynamics and behavior. The combination of optogenetics and large-scale neuronal recordings allows specific interneuron populations to be identified and perturbed for circuit analysis in intact animals. A crucial aspect of this approach is coupling electrophysiological recording with spatially and temporally precise light delivery.

Compassion-focused therapy with autistic adults.

Some autistic adults experience repeated adverse events, including rejection, victimization and stigmatization. They also describe others being critical and negatively judging them, such as for how they socially interact or for expressing passion for particular interests. The impact of these adverse events can be substantial, including increasing vulnerability for poorer mental health, and contributing to development of negative self beliefs (such as "I am different" or "I do not fit in") and shame-based difficulties.

Short-term auditory priming in freely-moving mice.

Priming, a change in the mental processing of a stimulus as a result of prior encounter with a related stimulus, has been observed repeatedly and studied extensively in humans. Yet currently, there is no behavioral model of short-term priming in lab animals, precluding research on the neurobiological basis of priming. Here, we describe an auditory discrimination paradigm for studying response priming in freely moving mice.

Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes.

Multiple biophysical mechanisms may generate non-negative extracellular waveforms during action potentials, but the origin and prevalence of positive spikes and biphasic spikes in the intact brain are unknown. Using extracellular recordings from densely-connected cortical networks in freely-moving mice, we find that a tenth of the waveforms are non-negative. Positive phases of non-negative spikes occur in synchrony or just before wider same-unit negative spikes.

BRCA1 deficiency in mature CD8 T lymphocytes impairs antitumor immunity.

Women with germline mutations have approximately an 80% lifetime chance of developing breast cancer. While the tumor suppressor function of BRCA1 in breast epithelium has been studied extensively, it is not clear whether deficiency in non-breast somatic cells also contribute to tumorigenesis. Here, we report that mouse knockout (KO) in mature T lymphocytes compromises host antitumor immune response to transplanted syngeneic mouse mammary tumors.

Cortical Pyramidal and Parvalbumin Cells Exhibit Distinct Spatiotemporal Extracellular Electric Potentials.

Brain circuits are composed of diverse cell types with distinct morphologies, connections, and distributions of ion channels. Modeling suggests that the spatial distribution of the extracellular voltage during a spike depends on cellular morphology, connectivity, and identity. However, experimental evidence from the intact brain is lacking.

Error correction and improved precision of spike timing in converging cortical networks.

The brain propagates neuronal signals accurately and rapidly. Nevertheless, whether and how a pool of cortical neurons transmits an undistorted message to a target remains unclear. We apply optogenetic white noise signals to small assemblies of cortical pyramidal cells (PYRs) in freely moving mice.