Endovascular Thrombectomy for Anterior Circulation Large Vessel Occlusion Stroke: An Evolution of Trials.

The last decade's progress in demonstrating the clinical benefit of endovascular thrombectomy (EVT) in patients with large vessel occlusion stroke has transformed the paradigm of care for these patients. This review presents the milestones in implementing EVT as standard of care, demonstrates the current state of evidence, provides guidance for identifying the candidate patient for EVT, and highlights unsolved and controversial issues. Ongoing trials investigate broadening of EVT indications for patients who present with large core infarction, adjunctive intra-arterial thrombolysis, medium vessel occlusion, low NIHSS, and tandem occlusion.

[Development of a program for automatic collection and archiving of clinical data of patients with dysfunction of the temporomandibular joint].

Objective: Development of a program for the automatic collection and archiving of clinical patients with TMJ dysfunction.

Material And Methods: Based on the clinical examination of 50 patients aged 18 to 30 years with temporomandibular joint dysfunction and the presence of an articular disc dislocation verified by magnetic resonance imaging, 80 signs were identified and terminologically formalized and were divided into 13 groups.

Results: This was the basis for the development of a detailed questionnaire for this contingent of patients, which the authors consider as the primary source of systematized data for processing in the program for automatic collection and archiving of clinical data.

[Familial hemiplegic migraine].

Hemiplegic migraine (HM) is a rare subtype of migraine with aura which prevalence is about 0.01%. The characteristic features include motor symptoms (hemiparesis) along with the signs of migraine with typical aura (visual, sensory and/or speech disturbances).

[Modern approach to the treatment of children with constant teeth avulsion].

The Aim Of The Study: Was to analyze treatment outcomes in children with constant teeth avulsion treated in Central Research Institute of Dentistry and Maxillofacial Surgery (CRIDMS).

Materials And Methods: The study comprised 39 children aged 7-16 years treated in CRIDMS in 2015-2020. In 38 cases from 39 replantation was performed more than 24 hours after trauma.

[Creating the conditions for skeletal traction in mandibular condyle fracture in children and adolescents].

In this article the possibility of using the Clark appliance (Twin-block) for creating conditions for skeletal traction in case of fraction of mandibular condyle in children and teenagers is presented. The proposed method of using the double-jaw orthodontic appliance Twin-block in case of mandibular fractures with condylar displacement promotes release of traumatized condyle and mandible replacement to correct position, promotes optimal conditions for myofunctional balance, fragment consolidation and remodeling of affected temporomandibular joint.

[Dental complications of the mandibular distraction osteogenesis].

The Aim Of The Study: Was to reveal the prevalence of dental abnormalities in children after mandibular distraction osteogenesis (MDO).

Materials And Methods: The study comprised 75 children aged 5-16 years (42 boys and 33 girls, mean age 9.8±4.

[The role of restorative oral rehabilitation in orthodontic treatment of cleft lip and palate patients].

Unlabelled: The purpose of the study is improving the effectiveness of rehabilitation of adolescents with a cleft lip and palate based on the orthopedic technologies implementation aimed at replacing the tooth-alveolar defect in the area of the alveolar ridge cleft at the active orthodontic treatment stage.

Materials And Methods: In the period from 2013 to 2020, 44 patients aged 10 to 18 years with unilateral and bilateral cleft lip and palate were observed. During orthodontic treatment with active appliances all patients received a removable plastic prosthesis with an artificial tooth (or several teeth) in it covering the defect of the alveolar process in the cleft area.

[Influence of different type of toothbrushes on gingival fluid proteolytic potential during orthodontic treatment].

The Aim: To study the effect of toothbrushes of various types on the accumulation of plaque and the proteolytic potential of gingival fluid as a pathogenic factors in long-term orthodontic treatment of patients with a distal permanent bite.

Material And Methods: We examined 63 patients of both sexes aged 11-18 years. Orthodontic treatment was carried out for the close position of the teeth with a distal permanent bite (K07.

[Maxillofacial manifestations in children and adolescents with neurofibromatosis 1].

The aim of the study was to summarize literature data on oral and maxillofacial manifestations of neurofibromatosis I (NFI) and to analyze clinical case in with dentist had the leading role in proper diagnosis of the disease. Literature review showed main oral alterations in NFI to be: neurofibroma formation seen in 8-14% of children and adolescents, dysplastic «orthodontic» phenotype with shortened mandible, maxilla and sphenoid bones; radiologic signs including alveolar nerve canal and mental foramen widening in almost one third of patients; lesions of cranial nerves (mainly trigeminal, facial and glossopharyngeal), with non-specific paralysis clinic. These symptoms, however, develop gradually throughout the life and may be evident only in late adolescents.

[Influence of different type of toothbrushes on the incidence of enamel demineralization and gingivitis in the course of orthodontic treatment].

The aim of the study was to determine the likelihood and frequency of complications, the impact of the use of various types of toothbrushes in the dynamics of orthodontic treatment with fixed appliances in patients with a distal permanent bite. The clinical study was conducted on 63 patients of both sexes, aged 11-18 years. Patients received long-term orthodontic treatment for a close tooth position with a distal permanent bite (K07.

[The prospects of collagen as a basis for curable and activated osteoplastic materials].

In the review, the structure and biological properties of collagen, variants of its production from natural sources and purification are considered. Methods for modifying the physico-mechanical properties of collagen to create a curable, highly purified collagen hydrogel are described. The advantages of a cured highly purified collagen hydrogel as a basis for osteoplastic material and a means of delivery of growth factors are indicated.

The role of external aetiological factors in dental anomalies in non-syndromic cleft lip and palate patients.

Aim: The hypothesis tested was whether proper tooth development in cleft lip and palate (CLP) patients is affected by early orthopaedic treatment (EOT), primary surgical interventions and palatal defects after primary palatoplasty.

Methods: The prospective study groups comprised 369 CLP children (aged 11.0 ± 4.

[Etiopathogenesis of obstructive sleep apnoea and its consequences in the children].

The article presents the modern view of etiology of the obstructive sleep apnoea/hypopnoea syndrome (OAHSS) in the children taking into consideration the ontogenetic stage and the principal mechanisms of its formation including the short-term and long-term consequences of sleep apnoea with special reference to the pathogenetic commonness of OAHSS with endothelial dysfunction, metabolic syndrome, cardiac disorders, and systemic chronic inflammation. The role of ENT diseases in the children with obstructive sleep apnoea is discussed. The results of genetic studies of the processes influencing the formation of the risk of development of sleep apnoea/hypopnoea syndrome and its outcomes in the children are discussed.

Thyrotropin levels and severity of symptoms in migraine patients of tertiary headache center.

Background: The role of thyroid regulation in migraine is poorly understood, and data is contradictory.

Objective: To study the possible association of clinical features of migraine with patients' thyroid function.

Patients And Methods: One hundred and thirty migraine patients of a tertiary headache center took part in an open-label, cross-sectional comparative study.

[Resorbable vs nonresorbable fixation in alveolar bone grafting in unilateral cleft lip and palate patients].

The aim of the study was to evaluate the resorbable vs nonresorbable fixation efficiency in bone grafting for unilateral cleft lip and palate (UCLP) patients. Thirty eight UCLP patients aged from 7 to 17 years (mean 11.5±3.

[Neurologic disturbances in children with cleft lip and cleft palate].

Aim: Neurological symptoms of genetic syndromes, including congenital cleft lip and palate (CLP) are well-studied while neurological characteristics of patients with non-syndromal CLP are not described. The authors studied neurological disturbances in CLP.

Material And Methods: Twenty-one patients with CLP, mean age 12.

[Risk factors for teeth aplasia and hypoplasia in cleft lip and palate children].

The aim of the study was to assess the significance of environmental risk factors for teeth aplasia and hypoplasia in cleft lip and palate children. Two hundred and forty-seven cleft lip and palate (CLP) children were enrolled in the study including 105 (42.5%) with bilateral CLP and 57.

[Modern approach to early orthopedic treatment in cleft lip and palate children].

The aim of the study was to enhance the quality of early orthopedic treatment in cleft lip and palate (CLP) children. Thirty-six infants aged 1 to 6 months were included in the study. The new method of early CLP orthopedic treatment using set of consecutive splints showed some advantages in compare with existing methods for alveolar bone deformity correction.

[Prenatal cleft palate diagnostics by structural and functional peculiarities of the tongue].

The aim of the study was to assess tongue position and function in cleft lip and palate children in order to use them for ultrasound prenatal diagnostics of this malformation. The study included 258 cleft lip and palate patients, as well as 2078 pregnant women (20-22 gestation weeks). The ultrasound scans of 39 cleft palate fetuses were evaluated retrospectively.

[Morphofunctional tongue features revealed by multispiral CT in cleft lip and palate patients].

Tongue structure and position as well as oral cavity volume were analyzed by means of multispiral CT in 82 cleft lip and palate patients and 27 healthy children. The study revealed microglossia and anomalous position and form of the tongue causing tongue tip to be pressed to the incisal part of the lower alveolar bone not exerting physiological impact on the upper alveolar bone. These results confirm the tongue position to be one of the factors for occlusion abnormalities in cleft lip and palate patients.

[Tongue structure, position and function in cleft lip and palate children assessed by ultrasound examination].

The aim of the study was to examine the position and function of the tongue in cleft lip and palate (CLP) patients and to reveal their impact on alveolar bone development. Two hundred and fifty-eight CLP children and 50 healthy children as control group were included in the study. Tongue function and position were assessed by ultrasound examination.

[Pantogam and pantogam active: qualitative and quantitative features of the interaction with neurotransmitter receptors in vitro].

We conducted a comparative study on the effect of active compounds of pantogam and pantogam active (calcium D(R)-homopantothenate and calcium DL(RS)-homopantothenate) and its L(S)-isomer on the receptors of main brain neuromediators in rats using in vitro radioligand binding analysis. All three compounds interact with binding sites of specific GABA-A and, in particular, GABA-B receptor ligands. Racemate and S-enantiomer, but not its R-form, competed to a moderate degree for D2-receptor binding sites.

[Clinical efficacy of cytoflavin in the combined treatment of patients during acute phase of ischemic stroke].

This study investigated efficiency of cytoflavin in combined treatment of acute hemisphere or stem stroke. It included 35 patients aged 40-70 years with the newly diagnosed mild and moderate stroke. The main group comprised 29 patients treated with cytoflavin (10 ml twice daily by i/v drop infusion for 10 days) in addition to basal therapy.

[Clinical features of migraine and parameters of trigeminal somatosensory evoked potentials in patients with different levels of thyroid-stimulating hormone].

Unlabelled: Levels of thyroid-stimulating hormone (TSH), trigeminal somatosensory evoked potentials (TSEPs) and quality of life (QoL) were studied in 50 migraine patients and 10 healthy subjects. The latency of P1 as well as the asymmetry of P1 latency and N1P1 amplitude were enlarged in migraine patients. Lower levels of TSH were correlated with more pronounced asymmetries in TSEPs.

[Echographic evaluation of anatomical bone structures peculiarities in children with two-sided cleft of upper lip and palate before and after early prosthetic treatment].

Ultrasound study of maxilla was performed in 74 patients with one-sided cleft of upper lip and palate (CULP) of the age from 1 month to 1.5 year. 49 patients with two-sided clefts got early prosthetic treatment with ultrasound investigation before the treatment beginning and after its completion.