Evolution of postoperative astigmatism after large incision PMMA lens implantation in children.

Purpose: To investigate the evolution of postoperative astigmatism after cataract extraction and lens implantation in children through a 6.5 mm limbal incision.

Methods: This is a retrospective longitudinal study of consecutive pediatric patients with adequate follow-up who underwent cataract extraction with intraocular lens implantation through a 6.

In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive.

Objective: To determine if a biodendrimer adhesive will seal a clear corneal cataract incision.

Design: An experimental study in which 2.75-mm clear corneal cataract incisions were made in 8 human donor eyes.

Keratomalacia caused by psychiatric-induced dietary restrictions.

Purpose: To describe the unique presentation, clinical course, management, and outcome of vitamin A deficiency-induced keratomalacia leading to bilateral corneal melts and ulcers in a patient with severe dietary restrictions because of psychiatric disease.

Methods: Review of patient's record and literature pertinent to her condition.

Results: A 33-year-old woman with a phobia of consuming most foods presented with bilateral corneal ulcers and melts from an unusual case of keratomalacia caused by vitamin A deficiency.

Role of corneal elasticity in damping of intraocular pressure.

Purpose: To determine corneal elasticity and its contribution in damping acute intraocular pressure spikes.

Methods: Twenty corneas with intact scleral rims were excised from human donor eyes and mounted on an artificial anterior chamber. A watertight seal was obtained with 17 corneas.

Photo cross-linkable Biodendrimers as ophthalmic adhesives for central lacerations and penetrating keratoplasties.

Purpose: Biodendrimer-based hydrogel adhesives were derived from biocompatible building blocks and poly(ethylene glycol) of 3,400, 10,000 and 20,000 g/mole. The leaking pressures were determined for these adhesives when used to seal 4.1-mm central lacerations and penetrating keratoplasties (PKPs) in enucleated porcine eyes.

Systemic and localized reversible regulation of transgene expression by tetracycline with tetR-mediated transcription repression switch.

Background: We recently developed a new tetracycline-inducible gene switch employing the tetracycline operator-containing hCMV major immediate-early promoter and the tetracycline repressor, tetR, rather than the previously used tetR-mammalian cell transcription factor fusion derivatives.

Materials And Methods: The present study demonstrates that this tetR-mediated transcription repression system can function as a powerful gene switch for On-and-Off regulation of therapeutic gene expression in ex vivo gene transfer protocols. Firstly, for achieving regulated gene expression in a localized tissue environment, R11/OEGF cells, a stable line that expresses hEGF under the control of the tetR-mediated transcription repression switch, were transplanted into porcine full-thickness wounds enclosed by wound chambers.

Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants.

A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel.

Hypopyon uveitis associated with systemic lupus erythematosus and antiphospholipid antibody syndrome.

Purpose: To report a case of hypopyon uveitis associated with systemic lupus erythematosus and antiphospholipid antibody syndrome.

Methods: Interventional case report: a 49-year-old woman with a history of systemic lupus erythematosus and antiphospholipid antibody syndrome presented with sudden onset of pain, redness, photophobia, and decreased vision in the left eye. Examination revealed hypopyon uveitis and vaso-occlusive retinopathy.