The effects of Hippophae rhamnoides in neuroprotection and behavioral alterations against iron-induced epilepsy.

Epilepsy is a neurological disorder in which malfunctioning of the electrical activity of the brain causes recurrent, unprovoked seizures. Epilepsy causes wide symptoms that include cognitive dysfunction, anxiety, behavioral alterations, and histological impairments. In this study, the effect of Hippophae rhamnoides (Sea buckthorn/Sbt) on electrophysiology, behavior, and histology in iron-induced epilepsy was analyzed.

Fisetin prevents the aging-associated decline in relative spectral power of α, β and linked MUA in the cortex and behavioral alterations.

Mental health in old age is of great concern due to the increased incidence of neurological and psychiatric diseases. With age, probability of cognitive and behavioral deficits increase and the prognosis deteriorates. Although a few in vitro studies have reported that flavonoid fisetin is beneficial for healthy aging, its effect on deteriorating mental health with aging in vivo is very limited and poorly understood.