Thiorphan, an inhibitor of neutral endopeptidase/enkephalinase (CD10/CALLA) enhances cell proliferation in bone marrow cultures of patients with acute leukemia in remission.

Thiorphan, (DL-mercapto-2-benzylpropanoyl)-glycine is a potent and specific inhibitor of membrane metallo-endopeptidase (EC 3.4.24.

[Skin cell culture: utilization in plastic surgery and laboratory studies].

Skin is the largest organ of the human body (8-10 kg, 1.5-2.0 m2, 10(11) cells of epidermal, mesenchymal and neural origin).

[Neuropeptides, endogenous opioid peptides and cell proliferation].

Neuropeptides are oligo- or polypeptidies having a number of common features including biosynthesis, metabolism and biological effectiveness at extremely low concentrations. They function as cotransmitters in the central, peripheral and autonomic nervous system. As autocrine, paracrine, neurocrine or endocrine factors, neuropeptides also directly modulate functions of many types of cells in different tissues, including the lymphoid tissue.

[[Long-term bone marrow culture].

Long-term bone marrow culture is an experimental in vitro model of hematopoiesis imitating conditions in vivo. It contains hematopoietic elements at various stages of differentiation as well as a supportive stromal microenvironment. Primitive hematopoietic stem cells of mesenchymal origin, the long-term culture initiating cells proliferate and differentiate into different cell types, giving rise to the adherent stromal layer and to various hematopoietic elements attached to it or floating freely in the supernatant medium.

Thiorphan stimulates clonal growth of GM-CFU in short-term cultures of bone marrow from a healthy donor and from patients with non-Hodgkin lymphoma.

Thiorphan, a specific inhibitor of membrane neutral endopeptidase (NEP, EC 3.4.24.

[Membrane metalloendopeptidase (CD10/CALLA): distribution, physiologic and pathophysiologic functions and its inhibitors].

Membrane metalloendopeptidase EC 3.4.24.