Primary Thyroid Lymphoma: A Rare Diagnosis Treated With Polatuzumab Vedotin.

Primary thyroid lymphoma is one of the rare and distinct type of extra nodal lymphomas originating within the thyroid gland. It accounts for less than 5% of all thyroid malignancies and 2% of extra nodal lymphomas. It predominantly affects older adults, with a higher incidence in women.

Minimally invasive tarsal arthrodesis in 15 dogs.

Objective: The aim of the present study was to report the outcomes and complications of minimally invasive tarsal arthrodesis (MITA) in dogs.

Study Design: Bi-institutional retrospective study.

Sample Population: A total of 15 client-owned dogs.

Virtual surgical planning and use of a 3D-printed, patient-specific reduction system for minimally invasive plate osteosynthesis of diaphyseal tibial fractures in dogs: A historic case control study.

Objective: To compare the efficacy and clinical outcomes of computed tomography (CT)-based virtual surgical planning (VSP) and a three-dimensional (3D)-printed, patient-specific reduction system to conventional indirect reduction techniques for diaphyseal tibial fractures stabilized using minimally invasive plate osteosynthesis (MIPO) in dogs.

Study Design: A prospective clinical study with a historic control cohort.

Sample Population: Dogs undergoing MIPO stabilization of diaphyseal tibial fractures using a custom 3D-printed reduction system (3D-MIPO; n = 15) or conventional indirect reduction techniques (c-MIPO; n = 14).

Blood transcriptomic signatures for symptomatic tuberculosis in an African multicohort study.

Background: Multiple host blood transcriptional signatures have been developed as non-sputum triage tests for tuberculosis (TB). We aimed to compare the diagnostic performance of 20 blood transcriptomic TB signatures for differentiating between symptomatic patients who have TB other respiratory diseases (ORD).

Methods: As part of a nested case-control study, individuals presenting with respiratory symptoms at primary healthcare clinics in Ethiopia, Malawi, Namibia, Uganda, South Africa and The Gambia were enrolled.

Efficacy of virtual surgical planning and a three-dimensional-printed, patient-specific reduction system to facilitate alignment of diaphyseal tibial fractures stabilized by minimally invasive plate osteosynthesis in dogs: A prospective clinical study.

Objective: To evaluate the efficacy of a three-dimensional (3D)-printed, patient-specific reduction system for aligning diaphyseal tibial fractures stabilized using minimally invasive plate osteosynthesis (MIPO).

Study Design: Prospective clinical trial.

Sample Population: Fifteen client owned dogs.

Mechanical evaluation of a threaded interference interlocking mechanism for angle-stable intramedullary nailing.

Objective: To assess the fatigue and load-to-failure mechanical characteristics of an intramedullary nail with a threaded interference design (TID) in comparison to a commercially available veterinary angle-stable nail with a Morse taper bolt design (I-Loc) of an equivalent size.

Methods: 10 single interlocking screw/bolt constructs of TID and I-Loc implants were assembled using steel pipe segments and placed through 50,000 cycles of simulated, physiologic axial or torsional loading. Entry torque, postfatigue extraction torque, and 10th, 25,000th, and 50,000th cycle torsional toggle were assessed.

Baseline and end-of-treatment host serum biomarkers predict relapse in adults with pulmonary tuberculosis.

Background: There is a need for new tools for monitoring of the response to TB treatment. Such tools may allow for tailored treatment regimens, and stratify patients initiating TB treatment into different risk groups. We evaluated combinations between previously published host biomarkers and new candidates, as tools for monitoring TB treatment response, and prediction of relapse.

Three-dimensionally printed osteotomy and reaming guides for correction of a multiplanar femoral deformity stabilized with an interlocking nail in a dog.

Objective: To describe the use of virtual surgical planning (VSP) and three-dimensionally (3D) printed surgical guides for corrective osteotomies stabilized with an interlocking nail in a dog with a multiplanar femoral deformity.

Study Design: Case report.

Animals: An 8-year-old male neutered mixed breed dog weighing 44 kg.

Mitigation of gap formation resulting from saw blade in single-cut osteotomy.

Bone loss from the kerf of the sawblade may influence the final outcomes when employing three-dimensional-printed surgical guides. However, no studies have systematically addressed saw blade-induced bone loss. This study aims to quantify bone loss and propose a reduction guide to minimize the fracture gap.

Complications and outcomes of total hip arthroplasty in dogs with luxoid hip dysplasia: 18 cases (2010-2022).

Objective: To describe the complications and outcomes in dogs with luxoid hip dysplasia (LH) undergoing total hip arthroplasty (THA) and compare complication rates with THA in non-LH dogs.

Study Design: Retrospective study.

Sample Population: Client-owned dogs (n = 217) undergoing primary THA (n = 238).

Principles and Practice of Antimicrobial Stewardship Program Resource Allocation.

Antimicrobial Stewardship Programs (ASP) improve individual patient outcomes and clinical care processes while reducing antimicrobial-associated adverse events, optimizing operational priorities, and providing institutional cost savings. ASP composition, resources required, and priority focuses are influenced by myriad factors. Despite robust evidence and broad national support, individual ASPs still face challenges in obtaining appropriate resources.

Deep learning discrimination of rheumatoid arthritis from osteoarthritis on hand radiography.

Purpose: To develop a deep learning model to distinguish rheumatoid arthritis (RA) from osteoarthritis (OA) using hand radiographs and to evaluate the effects of changing pretraining and training parameters on model performance.

Materials And Methods: A convolutional neural network was retrospectively trained on 9714 hand radiograph exams from 8387 patients obtained from 2017 to 2021 at seven hospitals within an integrated healthcare network. Performance was assessed using an independent test set of 250 exams from 146 patients.

Field evaluation of a point-of-care triage test for active tuberculosis (TriageTB).

Background: To improve tuberculosis (TB) diagnosis, the World Health Organisation (WHO) has called for a non-sputum based triage test to focus TB testing on people with a high likelihood of having active pulmonary tuberculosis (TB). Various host or pathogen biomarker-based testing devices are in design stage and require validity assessment. Host biomarkers have shown promise to accurately rule out active TB, but further research is required to determine generalisability.

Whole-genome sequencing rule-out of suspected hospital-onset outbreaks.

Two independent temporal-spatial clusters of hospital-onset infections were evaluated using whole-genome sequencing (WGS). Phylogenetic analysis confirmed that isolates within each cluster were unrelated despite epidemiological suspicion of outbreaks. The ITS1 region alone was insufficient for accurate analysis.

Biomechanical comparison of canine femurs implanted with either cemented (CFX) or cementless (with lateral bolt) (BFX+lb) total hip replacement under 4-point bending or torsional loads.

Compare biomechanical properties of femurs implanted with either BioMedtrix biological fixation with interlocking lateral bolt (BFX+lb) or cemented (CFX) stems when subjected to 4-point bending or axial torsional forces. Twelve pairs of normal medium to large cadaveric canine femora were implanted with a BFX + lb ( = 12) and a CFX ( = 12) stem-one in the right and one in the left femora of the pair. Pre- and post-operative radiographs were made.

Minimally invasive repair of acetabular fractures in dogs: Ex vivo feasibility study and case report.

Objective: To describe and evaluate minimally invasive repair of acetabular fractures in dogs using plates contoured to 3D-printed hemipelvic models.

Study Design: Ex vivo feasibility study and case report.

Sample Population: Adult canine cadavers (n = 5); 8 year old male neutered Chihuahua.

Minimally invasive plate osteosynthesis of femoral fractures with 3D-printed bone models and custom surgical guides: A cadaveric study in dogs.

Objective: Assess the accuracy and efficiency of reduction provided by application of plates precontoured to 3-dimensional (3D)-printed femoral bone models using a custom fracture reduction system (FRS) or intramedullary pin (IMP) to facilitate femoral minimally invasive plate osteosynthesis (MIPO) in dogs.

Study Design: Experimental cadaveric study.

Sample Population: Seven dog cadavers.

Serum acute-phase protein concentrations following uncomplicated total hip arthroplasty in dogs.

Objectives: To establish preoperative and postoperative serum C reactive protein (CRP) and serum amyloid A (SAA) levels in dogs undergoing uncomplicated total hip arthroplasty (THA).

Study Design: Prospective clinical trial.

Animals: Eighteen client-owned dogs.

Proximal femoral deformity correction and total hip arthroplasty in a dog using 3D printed custom guides.

Objective: To report the successful correction of a proximal femoral deformity (PFD) and total hip arthroplasty (THA) in a dog with the use of three-dimensionally (3D) printed custom surgical guides (CSGs).

Study Design: Case report.

Animals: One-year-old, male neutered, Goldendoodle.

Closed reduction and fluoroscopic-guided percutaneous pinning of femoral capital physeal or neck fractures: Thirteen fractures in 11 dogs.

Objectives: To report the short-term clinical outcome and complications in dogs that underwent surgical repair of femoral capital physeal or neck fractures via fluoroscopic-guided percutaneous pinning (FGPP).

Study Design: Retrospective case series.

Animals: Client owned dogs (n = 11) with femoral capital physeal or neck fractures (n = 13).

Efficacy of two reduction methods in conjunction with 3-D-printed patient-specific pin guides for aligning simulated comminuted tibial fractures in cadaveric dogs.

Objective: To assess the feasibility and accuracy of using 2 methods for reduction and alignment of simulated comminuted diaphyseal tibial fractures in conjunction with 3-D-printed patient-specific pin guides.

Sample: Paired pelvic limbs from 8 skeletally mature dogs weighing 20 to 35 kg.

Methods: CT images of both tibiae were obtained, and 3-D reconstructions of the tibiae were used to create proximal and distal patient-specific pin guides.

Transcriptional profiles predict treatment outcome in patients with tuberculosis and diabetes at diagnosis and at two weeks after initiation of anti-tuberculosis treatment.

Background: Globally, the tuberculosis (TB) treatment success rate is approximately 85%, with treatment failure, relapse and death occurring in a significant proportion of pulmonary TB patients. Treatment success is lower among people with diabetes mellitus (DM). Predicting treatment outcome early after diagnosis, especially in TB-DM patients, would allow early treatment adaptation for individuals and may improve global TB control.