Effect of STN DBS on vesicular monoamine transporter 2 and glucose metabolism in Parkinson's disease.

Introduction: Deep brain stimulation (DBS) is an established treatment for Parkinson's Disease (PD). Despite the improvement of motor symptoms in most patients by sub-thalamic nucleus (STN) DBS and its widespread use, the neurobiological mechanisms are not completely understood. The objective of the present study was to elucidate the effects of subthalamic nucleus (STN) DBS in PD on the dopamine system and neural circuitry, employing high-resolution positron emission tomography (PET) imaging.

Structures of metallosupramolecular coordination assemblies can be obtained by ion mobility spectrometry-mass spectrometry.

Rigid rectangular, triangular, and prismatic supramolecular assemblies, cyclobis[(2,9-bis[trans-Pt(PEt(3))(2)(PF(6))]anthracene)(4,4'-dipyridyl)], cyclotris[(2,9-bis[trans-Pt(PEt(3))(2)(PF(6))]phenanthrene)(4,4'-dipyridyl)], and cyclotris[bis[cis-Pt(PEt(3))(2)(CF(3)SO(3))(2)]tetrakis(4-pyridyl)cyclobutadienecyclopentadienylcobalt(I)], respectively, based on dipyridyl ligands and square planar platinum coordination, have been investigated by ion mobility spectrometry-mass spectrometry (IMS-MS). Electrospray ionization-quadrupole and time-of-flight spectra have been obtained and fragmentation pathways assigned. Ion mobility studies give cross sections that compare very well with cross sections of the supramolecular rectangle and triangle species on the basis of X-ray bond distances.

Primary pineal malignant melanoma.

Primary pineal malignant melanomas are a rare subset of primary central nervous system melanomas. This report presents the case of a 20-year-old female patient with a primary pineal region malignant melanoma who underwent endoscopic biopsy and adjuvant therapy. Her treatment consisted of stereotactic radiation to the pineal tumor, conventional whole-brain radiation and Temodar(R) for the disseminated disease.

Consideration of pitfalls in and omissions from the current ECG standards for diagnosis of myocardial ischemia/infarction in patients who have acute coronary syndromes.

The ECG is the key clinical test available for the emergency determination of which patients who presenting with acute coronary syndromes indeed have acute myocardial ischemia/infarction. Because typically the etiology is thrombosis, the correct clinical decision regarding reperfusion therapy is crucial. This review follows the efforts of an AHA working group to develop new standards for clinical application of electrocardiology.

Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chromosome 2.

A positive family history is a recognized cardiovascular risk factor, and genome-wide scans may reveal susceptibility loci for coronary artery disease. The acute coronary syndrome, consisting of myocardial infarction and unstable angina, is the most important manifestation of coronary disease and is characterized by atherosclerotic plaque disruption and coronary thrombosis. From approximately 6000 hospital admissions to cardiology units, we identified affected sibling pairs (n=61) who had documented acute coronary syndrome before the age of 70 years.