Click Chemistry Derived Hexa-ferrocenylated 1,3,5-Triphenylbenzene for the Detection of Divalent Transition Metal Cations.

The 1,3-dipolar cycloaddition reaction (click chemistry approach) was employed to create a hexa-ferrocenylated 1,3,5-triphenylbenzene derivative. Leveraging the presence of metal-chelating sites associated with 1,2,3-triazole moieties and 1,4-dinitrogen systems (ethylenediamine-like), as well as tridentate chelating sites (1,4,7-trinitrogen, diethylene triamine-like) systems, the application of this molecule as a chemosensor for divalent transition metal cations was investigated. The interactions were probed voltammetrically and spectrofluorimetrically against seven selected cations: iron(II) (Fe), cobalt(II) (Co), nickel(II) (Ni), copper(II) (Cu), zinc(II) (Zn), cadmium(II) (Cd), and manganese(II) (Mn).

Novel drug design framework as a response to neglected and emerging diseases.

A new drug design procedure, applicable in the circumstances of scarcity of experimental data, is proposed. The proposed method integrates and fragment-based drug design approaches. This protocol is uncomplicated, uses openly available resources and can be used to design new molecules that would inhibit the newly discovered or under researched targets.