Publications by authors named "Stanislav Spelda"
Article Synopsis
- ABT-751, an antimitotic agent, was tested alongside pemetrexed in a study involving 171 patients with advanced non-small-cell lung cancer (NSCLC) to evaluate its effectiveness and safety.
- Patients received either ABT-751 or a placebo over 21-day cycles, with the primary goal of measuring progression-free survival (PFS) and secondary outcomes including overall survival (OS) and pharmacokinetics.
- While overall results showed no significant improvement in PFS for the entire group, a notable benefit in OS was found in the squamous NSCLC subgroup, highlighting ABT-751’s potential in this specific patient population along with identified biomarkers that may predict survival outcomes.
Aim: The aim of this study is to evaluate the diagnostic yield of capsule endoscopy in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy in pigs.
Materials And Methods: Indomethacin (400 mg/day) was administrated orally for 10 days to eight female pigs weighing 36.3+/-2.
Article Synopsis
- The project aimed to create a method for using wireless video capsule endoscopy in preclinical research with pigs.
- Five female pigs were studied, and the capsule endoscopes recorded for a median of 492 minutes, reaching the cecum only once.
- The findings indicated that the small intestine's structure in pigs differs from humans, suggesting that this technique could aid future research on drug effects on the small bowel.
Background: We hypothesised that different solutions for submucosal injection may influence early healing of endoscopic mucosal resection (EMR). The aim of this study was to evaluate histological and immunological changes after EMR in experimental pigs.
Materials And Methods: Two parallel EMRs on the anterior and posterior wall of the gastric body were performed by means of the cap technique in 21 female pigs.
Objectives: The aim was the utilization of capsule microscopy and other diagnostic techniques for prospective pre-clinical research of absorption and biotransformation mechanisms of xenobiotics in the intestinal wall after induction of gastrointestinal dysfunction. Consequently, there is a demonstration of the extrems of gastrointestinal lesions development induced with indomethacin as a representative of non-steroidal anti-inflammatory drug.
Methods: The experimental animal species were small adult pigs (n=10; body weight 30-35 kg; 4-5 months old) used for their relative physiological and metabolic resemblance to man.
Sulphur containing radioprotective drugs amifostine (gammaphos, WR-2721) or cystamine (disulfide of meracaptoethylamine) of Czechoslovak production were examined in whole body fission neutrons irradiated rats in the thermal column of reactor VVR-S. Using the split-dose technic the first sublethal neutron dose in the range 1-2 Gy was followed by second lethal exposures in the two time intervals (3 or 6 days) using whole body fission neutrons irradiations (3 days interval) or whole body gamma-irradiations (6 days interval) for LD50/30 evaluation within next 30 days survival observation. In other experiments the mean survival time (MST) in days was estimated in different rats group, when animals were whole body fission neutrons irradiated twice with 3-days interval using the total lethal doses of 4 or 5 Gy.
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