Publications by authors named "Stanislav G Terekhin"
New approaches to the design of analgesic medicinal substances.
Ilia V Rogachevskii Vera B Plakhova Valentina A Penniyaynen Stanislav G Terekhin Svetlana A Podzorova
Can J Physiol Pharmacol
January 2022
Article Synopsis
- Comenic acid, a gamma-pyrone derivative, activates opioid-like receptors that influence Na1.8 channels in sensory neurons, suggesting its potential as a pain-reliever.
- This research uniquely combines live neuron data with quantum chemical calculations to explore how gamma-pyrone structures relate to their physiological effects.
- The study highlights the importance of calcium binding in gamma-pyrones, which alters their electrostatic properties and facilitates ligand-receptor interactions crucial for their analgesic activity.
Comenic acid (CA), a specific agonist of opioid-like receptors, effectively and safely relieves neuropathic pain by decreasing the Na1.8 channel voltage sensitivity in the primary sensory neuron membrane. CA triggers downstream signaling cascades, in which the Na,K-ATPase/Src complex plays a key role.
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