Aс/Bi generator for direct synthesis of Bi-labeled bioconjugates.

Background: Bi is a short-lived radionuclide currently trialed for alpha therapy of various oncological diseases. A serious obstacle to the wide medical use is decay losses of Bi during a conventional synthesis of radiopharmaceuticals. In this work, we aimed to develop a two-column Aс/Bi generator providing the accumulation of Bi separately from the parent Ac via continuous circular separation and decay of intermediate Fr.

Insights into Actinium Complexes with Tetraacetates─AcBATA versus AcDOTA: Thermodynamic, Structural, and Labeling Properties.

In the current research, we conducted a comparative study of the Ac complex with HDOTA and HBATA. The stability constants of the [AcBATA] and [AcDOTA] complexes were studied directly by extraction methods. We discovered that the thermodynamic properties of the [AcBATA] complex are superior to those of [AcDOTA].

Rapid Elution of Th from a Two-Column U/Th Generator with Diluted and Buffer Solutions.

A radionuclide generator of the short-lived alpha emitter Th was proposed. An original scheme consisting of two in-series chromatographic columns was developed for rapidly producing a neutral citric-buffered eluate of high purity Th. The first column filled with TEVA resin retained the parent U, while Th was eluted with 7 M HCl solution to be immediately adsorbed on the second column containing DGA resin or UTEVA resin.

DTPA(DOTA)-Nimotuzumab Radiolabeling with Generator-produced Thorium for Radioimmunotherapy of EGFR-overexpressing Carcinomas.

Introduction: The feasibility of preparing the "in-house" generators and the Th- DTPA(DOTA)-Nimotuzumab radioimmunoconjugate was evaluated. Th is perspective for TAT, however, due to short half-life it is preferable to apply this radionuclide for readily available epithelial malignancies. Nimotuzumab being specific for EGFR expressing cells as a targeting moiety is considered to be suitable for thorium delivery.

A Radionuclide Generator of High-Purity Bi-213 for Instant Labeling.

A new two-column Ac/Bi generator was developed specifically for using Ac containing an impurity of long lived Ac. The parent Ac was retained on the first Actinide Resin column, while Bi was accumulated on the second column filled with AG MP-50 resin via continuous elution and decay of intermediate Fr. The Bi accumulation was realized in circulation mode which allowed a compact generator design.