Protective Effect of Methylxanthine Fractions Isolated from Tea Leaves against Doxorubicin-Induced Cardio- and Nephrotoxicities in Rats.

is an anthracycline antibiotic that is used for the treatment of various types of cancer. However, its clinical usage is limited due to its potential life-threatening adverse effects, such as cardio- and nephrotoxicities. Nonetheless, simultaneous administration of and antioxidants, such as those found in leaves, could reduce cardiac and renal tissue damage caused by oxidative stress.