Publications by authors named "Stanchev H"

Group B Streptococcus (GBS) disease in neonates occurs in two forms: early-onset disease (EOD), (day 0-6), and late-onset disease (LOD), (day 7-90). This review investigates that risk-based intrapartum screening and antibiotics have reduced the incidence of EOD, but not LOD, in Denmark. No clinical or laboratory tests can rule out GBS disease at symptom onset.

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Article Synopsis
  • - The study evaluated the effectiveness of switching from intravenous to oral antibiotics (amoxicillin) for treating neonates with early-onset infection (EOI) and included data from 835 term-born neonates over two years.
  • - Results showed that 90% of neonates with probable infection successfully switched to oral therapy, with no readmissions due to infection and a shorter average hospital stay compared to those on intravenous therapy.
  • - Although oral therapy proved safe and beneficial for easing the treatment process, the overall use of antibiotics did not increase after implementing switch therapy.
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Introduction: Early in-home care is increasingly being used in Scandinavian countries for clinically stable premature infants. Due to challenges with travel and hospital resources, alternative ways to support parents during early in-home care are being considered. The aim of this study was to test whether the proportion of mothers exclusively breastfeeding, parental confidence and mother-infant interaction increased after early in-home care with premature infants, and to compare the outcomes of in-home care involving the use of video communication and a mobile application with those of in-home care involving in-hospital consultations.

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Introduction: Although premature infants and their parents are discharged earlier to inhomecare programmes, how to optimally support parents during this transition remains unknown. The aim of this study is to compare the effects of early inhomecare (PreHomeCare) including video consultations and mobile applications with those of inhospital consultations regarding breast feeding, parental confidence and parent-infant interactions.

Methods And Analysis: A randomised controlled intervention study will be conducted in four neonatal departments offering PreHomeCare (ie, premature infant inhomecare) in Denmark.

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Aim: Respiratory distress syndrome (RDS) is a major cause of mortality and morbidity in premature infants. By the time symptoms appear, it may already be too late to prevent a severe course, with bronchopulmonary dysplasia or mortality. We aimed to develop a rapid test of lung maturity for targeting surfactant supplementation.

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Aim: Preterm birth is often associated with prolonged hospitalisation, complicating the parent-child relationship and breastfeeding rates. As a result, an early discharge programme was implemented in the department of neonatology at Rigshospitalet. The infants were stable, but required tube feeding, and during the programme, they received home visits by neonatal nurses.

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Human parechovirus type 3 (HPeV3) can cause meningoence-phalitis which is difficult to distinguish from enterovirus (EV) or herpes simplex virus (HSV) meningoencephalitis. EV and HSV meningoencephalitis can appear without cerebrospinal fluid (CSF) pleocytosis. Our case was an eight-day-old girl who had seizures but lacked CSF pleocytosis.

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Background: We have developed a rapid method, based on lamellar body counts (LBC) on gastric aspirate, for identifying newborns who will develop respiratory distress syndrome with a need for surfactant supplementation.

Objective: We set out to test whether it was possible to improve the outcome when used in a clinical trial.

Methods: We randomly assigned 380 infants born at 24-29 weeks' gestation and supported with nasal continuous positive airway pressure (nCPAP) to receive surfactant guided either by LBC (intervention group) or increasing need for oxygen (control group).

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Aim: To develop a rapid method for diagnosing lung maturity at birth with the purpose of administering surfactant early to infants with immature lungs and to spare infants with mature lungs from this treatment.

Methods: Lamellar body counts (LBC) on gastric aspirates from 191 newborns were counted in the platelet window in automatic blood cell counters. A preliminary study was performed on 108 aspirates from 2000 in infants with <32 weeks' gestation.

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Objective: To assess agreement between Cochrane Neonatal Group reviews and clinical practice guidelines in Denmark.

Design: Retrospective analysis of clinical guidelines for newborn infants.

Materials: All Cochrane neonatal reviews and Danish clinical guidelines for newborn infants.

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The effect of 0.3, 3 and 10 mg SeO2 added to chicken ration on in vitro absorption of 35S-thiamine and its content in brain and liver have been studied. Addition of SeO2 inhibits thiamine absorption in chicken jejunum.

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