Ethical Decision-Making at the Bedside.

Actions nurses can take to ensure accurate and appropriate care.

Toll-like receptor 7 protects against intestinal inflammation and restricts the development of colonic tissue-resident memory CD8 T cells.

Introduction: The maintenance of intestinal homeostasis depends on a complex interaction between the immune system, intestinal epithelial barrier, and microbiota. Alteration in one of these components could lead to the development of inflammatory bowel diseases (IBD). Variants within the autophagy gene have been implicated in susceptibility and severity of Crohn's disease (CD).

Impact of the 2008 7.9 Great Wenchuan earthquake on South China microplate motion.

Tectonic plate motions drive the earthquake cycle, as they result in the slow accrual and sudden release of energy along plate boundaries. Steadiness of plate motions over the earthquake cycle is a central tenet of the plate tectonics theory and has long been a main pillar in models of earthquake genesis, or of plate-margins seismic potential inferred from slip-deficit estimates. The advent of geodesy in the geosciences and the availability of multi-year-long series of position measurements permit tracking the motions of tectonic plates from before to after the time of significant seismic events that occur along their margins.

A Mentoring Initiative for Students at Historically Black Colleges and Universities: One Strategy to Increase Nursing Workforce Diversity and Advance Health Equity.

This article addresses low retention and graduation rates among historically marginalized students in nursing programs at Historically Black Colleges and Universities (HBCUs). Mentoring is a proven success strategy to support systems for historically marginalized students, helping them navigate challenges, improving academic outcomes, and increasing the diversity of the nursing workforce. The article highlights the mentoring initiative of AARP's Center for Health Equity through Nursing and the Future of Nursing: Campaign for Action, an initiative of AARP Foundation, AARP, and the Robert Wood Johnson Foundation, and the outcomes of this collaboration.

A Culture of Inclusion in Nursing Can Provide a Foundation for Belonging: A Key to Greater Retention of the Nursing Workforce.

Increasing global migration necessitates a larger, more diverse, and more culturally responsive nursing workforce. If health care organizations are to foster a culture of inclusion, they must employ strategies to retain the current nursing workforce and prepare for greater diversity in the future. Nurses are leaving the profession for many reasons.

Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.

Objective: Perianal Crohn's disease (pCD) occurs in up to 40% of patients with CD and is associated with poor quality of life, limited treatment responses and poorly understood aetiology. We performed a genetic association study comparing CD subjects with and without perianal disease and subsequently performed functional follow-up studies for a pCD associated SNP in ().

Design: Immunochip-based meta-analysis on 4056 pCD and 11 088 patients with CD from three independent cohorts was performed.

DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury.

Background & Aims: Tumor necrosis factor (TNF) superfamily member tumor necrosis factor-like protein 1A (TL1A) has been associated with the susceptibility and severity of inflammatory bowel diseases. However, the function of the tumor necrosis factor-like protein 1A and its receptor death receptor 3 (DR3) in the development of intestinal inflammation is incompletely understood. We investigated the role of DR3 expressed by intestinal epithelial cells (IECs) during intestinal homeostasis, tissue injury, and regeneration.

GPS data from 2019 and 2020 campaigns in the Chesapeake Bay region towards quantifying vertical land motions.

The Chesapeake Bay is a region along the eastern coast of the United States where sea-level rise is confounded with poorly resolved rates of land subsidence, thus new constraints on vertical land motions (VLM) in the region are warranted. In this paper, we provide a description of two campaign-style Global Positioning System (GPS) datasets, explain the methods used in data collection and validation, and present the experiment designed to quantify a new baseline of VLM in the Chesapeake Bay region of eastern North America. Data from GPS campaigns in 2019 and 2020 are presented as ASCII RINEX2.

BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis.

The intestinal immune system and microbiota are emerging as important contributors to the development of metabolic syndrome, but the role of intestinal dendritic cells (DCs) in this context is incompletely understood. BATF3 is a transcription factor essential in the development of mucosal conventional DCs type 1 (cDC1). We show that mice developed metabolic syndrome and have altered localization of tight junction proteins in intestinal epithelial cells leading to increased intestinal permeability.

Multisite Integrated Health System Utilizes Proactive Community Strategies to Address Vaccine Hesitancy and Create Positive Change.

Vaccine hesitancy remains a barrier to successful COVID-19 vaccination programs across all populations. Attempts to mitigate this barrier, including mandates, have not been successful, especially in communities of color where the vaccination rates remain low. Nursing leadership, diversity, equity, and inclusion officers, and C-suite executives of 1 health system collaborated to address vaccine hesitancy through various community conversations with health care workers, non-direct caregivers, nursing students, and all populations across 4 state counties.

Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo.

Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease, modulating the location and severity of inflammation and fibrosis. TL1A expression is increased in inflamed mucosa and associated with fibrostenosing Crohn's disease. Tl1a-overexpression in mice causes spontaneous ileitis, and exacerbates induced proximal colitis and fibrosis.

Nurse Leaders Advocate for Nurses Across a Health Care System: COVID-19.

The COVID-19 pandemic emphasizes the importance of nursing care globally. Nurses are the frontline staff in the care of individuals stricken with this highly infectious and deadly illness. Nurse leaders must advocate for nursing staff when staff are immersed in often overwhelming conditions.

Sustainably reducing device utilization and device-related infections with DeCATHlons, device alternatives, and decision support.

Engagement of frontline staff, along with senior leadership, in competition-style healthcare-associated infection reduction efforts, combined with electronic clinical decision support tools, appeared to reduce antibiotic regimen initiations for urinary tract infections (P = .01). Mean monthly standardized infection and device utilization ratios also decreased (P < .

Victoria continental microplate dynamics controlled by the lithospheric strength distribution of the East African Rift.

The Victoria microplate between the Eastern and Western Branches of the East African Rift System is one of the largest continental microplates on Earth. In striking contrast to its neighboring plates, Victoria rotates counterclockwise with respect to Nubia. The underlying cause of this distinctive rotation has remained elusive so far.

Author Correction: A Geodetic Strain Rate Model for the East African Rift System.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A Geodetic Strain Rate Model for the East African Rift System.

Here we describe the new Sub-Saharan Africa Geodetic Strain Rate Model v.1.0 (SSA-GSRM v.

Holiday season for a healthy heart.

The term "holiday heart" is defined as an acute cardiac arrhythmia or conduction disturbance associated with heavy alcohol intake in individuals with no known heart disease, but in whom heart rhythm is restored to normal with abstinence of alcohol. This article provides a brief overview of the literature on this topic, discusses causes of increased cardiac events during the holiday season, describes a patient profile and the effect on patients' health as well as on their families, and provides suggestions to decrease the risk of holiday heart during the festive season.

Strain accommodation by slow slip and dyking in a youthful continental rift, East Africa.

Continental rifts begin and develop through repeated episodes of faulting and magmatism, but strain partitioning between faulting and magmatism during discrete rifting episodes remains poorly documented. In highly evolved rifts, tensile stresses from far-field plate motions accumulate over decades before being released during relatively short time intervals by faulting and magmatic intrusions. These rifting crises are rarely observed in thick lithosphere during the initial stages of rifting.