Bio-equivalence of IM and SQ H.P. Acthar Gel.

Objective: IM Acthar Gel (Acthar) is a natural-source ACTH used for the treatment of MS exacerbations. It is not known if subcutaneous (SQ) administration of Acthar is equivalent to IM administration or if lower doses of Acthar would provide comparable serum cortisol responses.

Methods: We compared IM and SQ administration of Acthar to explore bio-equivalency between the two routes of administration.